Gene therapy has gained significant attention over the past two decades as a potential
method for treating genetic disorders such as severe combined immunodeficiency, 1 cystic …

Stimuli-responsive polymers show a sharp change in properties upon a small or modest
change in environmental condition, eg temperature, light, salt concentration or pH. This …

A series of novel bioreducible poly (amido amine) s containing multiple disulfide linkages
(SS-PAAs) were synthesized and evaluated as nonviral gene vectors. These linear SS-PAAs …

Abstract Poly (amido‐amine) s (PAAs) are synthetic tert‐amino polymers obtained by
stepwise polyaddition of primary or secondary aliphatic amines to bis (acrylamide) s. Linear …

Non-viral gene delivery systems are one of the most potential alternatives to viral vectors
because of their less immunogenicity, less toxicity and easy productivity in spite of their low …

Controlling interactions in synthetic polymers as precisely as in proteins would have a strong
impact on polymer science. Advanced structural and functional control can lead to rational …

There are now at least seven polymer–drug conjugates that have entered phase I/II clinical
trial as anticancer agents. These include N-(2-hydroxypropyl) methacrylamide (HPMA) …

A group of novel poly (amido amine) homo-and copolymers (PAAs) containing secondary
and tertiary amine groups in their main chain and different structures in the bisacrylamide …

A novel synthesis route toward multifunctional, sequence-defined polyamides is described.
A fully automated, solid-phase supported polymer synthesis was developed and utilized to …

Stimuli-responsive, smart, intelligent, or environmentally sensitive polymers respond to
changes in external stimuli such as pH, temperature, ionic strength, surfactants, pressure …