Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …

HIV prevalence is increasing worldwide because people on antiretroviral therapy are living
longer, although new infections decreased from 3· 3 million in 2002, to 2· 3 million in 2012 …

Clonal expansion of infected CD4+ T cells is a major mechanism of HIV-1 persistence and a
barrier to achieving a cure. Potential causes are homeostatic proliferation, effects of HIV-1 …

A latent reservoir for HIV-1 in resting CD4+ T lymphocytes precludes cure. Mechanisms
underlying reservoir stability are unclear. Recent studies suggest an unexpected degree of …

Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …

The mechanisms responsible for the persistence of HIV-1 after many years of suppressive
antiretroviral therapy (ART) have been only partially elucidated. Most of the studies …

The possibility of HIV-1 eradication has been limited by the existence of latently infected
cellular reservoirs. Studies to examine control of HIV latency and potential reactivation have …

Although antiretroviral therapy (ART) is highly effective at suppressing HIV-1 replication, the
virus persists as a latent reservoir in resting CD4+ T cells during therapy. This reservoir …

Background Quantifying latently infected cells is critical to evaluate the efficacy of
therapeutic strategies aimed at reducing the size of the long-lived viral reservoir, but the low …

Although gut and lymph node (LN) memory CD4 T cells represent major HIV and simian
immunodeficiency virus (SIV) tissue reservoirs, the study of the role of dendritic cells (DCs) …