Over the past decade, preclinical and clinical research have confirmed the essential role of
interferons for effective host immunological responses to malignant cells. Type I interferons …

Acute exposure of cancer cells to high concentrations of type I interferon (IFN-I) drives
growth arrest and apoptosis, whereas chronic exposure to low concentrations provides …

Cancer stem cells (CSCs) are a subpopulation of cancer cells endowed with high
tumorigenic, chemoresistant and metastatic potential. Nongenetic mechanisms of acquired …

Triple-negative breast cancer (TNBC) is cancer that tested as negative for estrogen
receptors (ER), progesterone receptors (PR), and excess human epidermal growth factor …

The efficacy of several therapeutic strategies against cancer, including cytotoxic drugs,
radiotherapy, targeted immunotherapies and oncolytic viruses, depend on intact type I …

Cancer stem cells (CSCs) are subpopulations of tumor cells with the ability to self-renew,
differentiate, and initiate and maintain tumor growth, and they are considered to be the main …

Cancer stem cells (CSCs) are a subpopulation of cells within tumors that possess the stem
cell characteristics of self-renewal, quiescence, differentiation, and the ability to recapitulate …

Interferons (IFNs) are pleiotropic cytokines critical for regulation of epithelial cell functions
and for immune system regulation. In cancer, IFNs contribute to tumor-intrinsic and-extrinsic …

Triple-negative breast cancer (TNBC) is a heterogeneous group of tumors characterized by
aggressive behavior, high risk of distant recurrence, and poor survival. Chemotherapy is still …

Ligand-dependent corepressor (LCOR) mediates normal and malignant breast stem cell
differentiation. Cancer stem cells (CSCs) generate phenotypic heterogeneity and drive …