Gut associated metabolites and their roles in Clostridioides difficile pathogenesis

AM Aguirre, JA Sorg - Gut Microbes, 2022 - Taylor & Francis
The nosocomial pathogen Clostridioides difficile is a burden to the healthcare system. Gut
microbiome disruption, most commonly by broad-spectrum antibiotic treatment, is well …

New treatment approaches for Clostridioides difficile infections: alternatives to antibiotics and fecal microbiota transplantation

T Bratkovič, A Zahirović, M Bizjak, M Rupnik… - Gut …, 2024 - Taylor & Francis
Clostridioides difficile causes a range of debilitating intestinal symptoms that may be fatal. It
is particularly problematic as a hospital-acquired infection, causing significant costs to the …

Determinants of developability and evolvability of synthetic miniproteins as ligand scaffolds

A McConnell, SL Batten, BJ Hackel - Journal of Molecular Biology, 2023 - Elsevier
Binding ligands empower molecular therapeutics and diagnostics. Despite an array of
protein scaffolds engineered for binding, the biophysical elements that drive developability …

[PDF][PDF] FACTORS THAT AFFECT CLOSTRIDIOIDES DIFFICILE INFECTIONS USING IN VIVO AND IN VITRO APPROACHES

AM AGUIRRE - 2022 - oaktrust.library.tamu.edu
ABSTRACT C. difficile a Gram-positive, spore-forming, pathogenic bacterium, is the leading
cause of nosocomial-associated diarrhea in the United States. C. difficile is characterized as …