Phenotypic heterogeneity, defined as metastable variation in cellular parameters generated
by epigenetic mechanisms, is crucial for the persistence of bacterial populations under …

In prokaryotes, DNA can be segregated by three different types of cytoskeletal filaments. The
best-understood type of partitioning (par) locus encodes an actin homolog called ParM …

Visualization of living E. coli nucleoids, defined by HupA-mCherry, reveals a discrete,
dynamic helical ellipsoid. Three basic features emerge.(1) Nucleoid density coalesces into …

The organization of the Escherichia coli chromosome into insulated macrodomains
influences the segregation of sister chromatids and the mobility of chromosomal DNA. Here …

The FtsZ protein, a tubulin-like GTPase, plays a pivotal role in prokaryotic cell division. In
vivo it localizes to the midcell and assembles into a ring-like structure-the Z-ring. The Z-ring …

Structural maintenance of chromosomes (SMC) complexes organize chromosomes
ubiquitously, thereby contributing to their faithful segregation. We demonstrate that under …

The organization of the Escherichia coli chromosome has been defined genetically as
consisting of four insulated macrodomains and two less constrained regions. Here we have …

For growth and division of rod-shaped bacteria, the cylindrical part of the sacculus has to be
elongated and two new cell poles have to be synthesized. The elongation is performed by a …

A prevalent view of DNA replication has been that it is carried out in fixed" replication
factories." By tracking the progression of sister replication forks with respect to genetic loci in …

Bacteriophage lambda infection of Escherichia coli can result in distinct cell fate outcomes.
For example, some cells lyse whereas others survive as lysogens. A quantitative biophysical …