[HTML][HTML] Tuberculosis and lung damage: from epidemiology to pathophysiology

S Ravimohan, H Kornfeld, D Weissman… - European respiratory …, 2018 - Eur Respiratory Soc
A past history of pulmonary tuberculosis (TB) is a risk factor for long-term respiratory
impairment. Post-TB lung dysfunction often goes unrecognised, despite its relatively high …

Innate immunity in tuberculosis: host defense vs pathogen evasion

CH Liu, H Liu, B Ge - Cellular & molecular immunology, 2017 - nature.com
The major innate immune cell types involved in tuberculosis (TB) infection are
macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells. These immune …

[HTML][HTML] Host evasion and exploitation schemes of Mycobacterium tuberculosis

CJ Cambier, S Falkow, L Ramakrishnan - Cell, 2014 - cell.com
Tuberculosis, an ancient disease of mankind, remains one of the major infectious causes of
human death. We examine newly discovered facets of tuberculosis pathogenesis and …

Revisiting the role of the granuloma in tuberculosis

L Ramakrishnan - Nature Reviews Immunology, 2012 - nature.com
The granuloma, which is a compact aggregate of immune cells, is the hallmark structure of
tuberculosis. It is historically regarded as a host-protective structure that'walls off'the infecting …

Macrophages in tuberculosis: friend or foe

E Guirado, LS Schlesinger, G Kaplan - Seminars in immunopathology, 2013 - Springer
Tuberculosis (TB) remains one of the greatest threats to human health. The causative
bacterium, Mycobacterium tuberculosis (Mtb), is acquired by the respiratory route. It is …

Cavitary tuberculosis: the gateway of disease transmission

ME Urbanowski, AA Ordonez… - The Lancet Infectious …, 2020 - thelancet.com
Tuberculosis continues to be a major threat to global health. Cavitation is a dangerous
consequence of pulmonary tuberculosis associated with poor outcomes, treatment relapse …

Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium

HE Volkman, TC Pozos, J Zheng, JM Davis, JF Rawls… - Science, 2010 - science.org
Granulomas, organized aggregates of immune cells, are a hallmark of tuberculosis and
have traditionally been thought to restrict mycobacterial growth. However, analysis of …

Drylands in the earth system

DS Schimel - Science, 2010 - science.org
Arid regions (or drylands) cover about 45% of Earth's land surface; in most classifications of
ecosystem types, they constitute the largest biome on the planet. Yet the global change …

Tuberculosis, pulmonary cavitation, and matrix metalloproteinases

CWM Ong, PT Elkington, JS Friedland - American journal of …, 2014 - atsjournals.org
Tuberculosis (TB), a chronic infectious disease of global importance, is facing the
emergence of drug-resistant strains with few new drugs to treat the infection. Pulmonary …

Immunity and immunopathology in the tuberculous granuloma

AJ Pagán, L Ramakrishnan - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Granulomas, organized aggregates of immune cells, are a defining feature of tuberculosis
(TB). Granuloma formation is implicated in the pathogenesis of a variety of inflammatory …