The advent of efficient approaches to the genetic modification of T cells has provided
investigators with clinically appealing methods to improve the potency of tumor‐specific …

CD4 T cells have been implicated in cancer immunity for their helper functions. Moreover,
their direct cytotoxic potential has been shown in some patients with cancer. Here, by mining …

The in vivo persistence of adoptively transferred T cells is predictive of antitumor response.
Identifying functional properties of infused T cells that lead to in vivo persistence and tumor …

Engineered crystallizable fragment (Fc) regions of antibody domains, which assume a
unique and unprecedented asymmetric structure within the homodimeric Fc polypeptide …

The efficacy of most therapeutic monoclonal antibodies (mAbs) targeting tumor antigens
results primarily from their ability to elicit potent cytotoxicity through effector-mediated …

T cells genetically modified to express a CD19-specific chimeric antigen receptor (CAR) for
the investigational treatment of B-cell malignancies comprise a heterogeneous population …

The adaptive immune system is known to play an important role in anti-neoplastic responses
via induction of several effector pathways, resulting in tumor cell death. Because of their …

Chimeric antigen receptor (CAR) T cell show promise in cancer treatments, but their
mechanism of action is not well understood. Decoding the mechanisms used by individual T …

Purpose: Adoptive T-cell therapy using autologous tumor-infiltrating lymphocytes (TIL) has
shown an overall clinical response rate 40%–50% in metastatic melanoma patients. BTLA …

Chimeric antigen receptor (CAR) T cells used for the treatment of B cell malignancies can
identify T cell subsets with superior clinical activity. Here, using infusion products of …