Summary (Macro) autophagy is a fundamental degradation process for macromolecules and
organelles of vital importance for cell and tissue homeostasis. Autophagy research has …

Cytosolic Ca 2+ concentration levels fluctuate in an ordered manner along the cell cycle, in
line with the fact that Ca 2+ is involved in the regulation of cell proliferation. Cell proliferation …

Background Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many
myeloproliferative neoplasms, but the molecular pathogenesis of myeloproliferative …

Patients with essential thrombocythemia may carry JAK2 (V617F), an MPL substitution, or a
calreticulin gene (CALR) mutation. We studied biologic and clinical features of essential …

Calreticulin (CALR) mutations were recently described in JAK2 and MPL unmutated primary
myelofibrosis (PMF) and essential thrombocythemia. In the current study, we compared the …

Anticancer drugs continue to cause significant reductions in left ventricular ejection fraction
resulting in congestive heart failure. The best-known cardiotoxic agents are anthracyclines …

Ticks are hematophagous arachnids transmitting a wide variety of pathogens including
viruses, bacteria, and protozoans to their vertebrate hosts. The tick vector competence has to …

Mutations in signaling molecules of the cytokine receptor axis play a central role in
myeloproliferative neoplasm (MPN) pathogenesis. Polycythemia vera is mainly related to …

Helenius and colleagues proposed over 20‐years ago a paradigm‐shifting model for how
chaperone binding in the endoplasmic reticulum was mediated and controlled for a new …

Immunogenic cell death (ICD) is a regulated cell death (RCD) pathway. In response to
physical and chemical signals, tumor cells activate specific signaling pathways that stimulate …