[HTML][HTML] Stem cell aging in skeletal muscle regeneration and disease

H Yamakawa, D Kusumoto, H Hashimoto… - International journal of …, 2020 - mdpi.com
Skeletal muscle comprises 30–40% of the weight of a healthy human body and is required
for voluntary movements in humans. Mature skeletal muscle is formed by multinuclear cells …

[HTML][HTML] Spatiotemporal transcriptomic atlas reveals the dynamic characteristics and key regulators of planarian regeneration

G Cui, K Dong, JY Zhou, S Li, Y Wu, Q Han… - Nature …, 2023 - nature.com
Whole-body regeneration of planarians is a natural wonder but how it occurs remains
elusive. It requires coordinated responses from each cell in the remaining tissue with spatial …

[HTML][HTML] Role of BET inhibitors in triple negative breast cancers

D Khandekar, V Tiriveedhi - Cancers, 2020 - mdpi.com
Bromodomain and extraterminal domain (BET) proteins have evolved as key multifunctional
super-regulators that control gene expression. These proteins have been shown to …

Sepsis induces muscle atrophy by inhibiting proliferation and promoting apoptosis via PLK1‐AKT signalling

YY Cao, Z Wang, T Yu, Y Zhang… - Journal of Cellular …, 2021 - Wiley Online Library
Sepsis and sepsis‐induced skeletal muscle atrophy are common in patients in intensive
care units with high mortality, while the mechanisms are controversial and complicated. In …

Silk sericin patches delivering miRNA-29-enriched extracellular vesicles-decorated myoblasts (SPEED) enhances regeneration and functional repair after severe …

Y Song, M Li, S Lei, L Hao, Q Lv, M Liu, G Wang… - Biomaterials, 2022 - Elsevier
Severe skeletal muscle injuries usually lead to a series of poor recovery issues, such as
massive myofibers loss, scar tissue formation, significant muscle function impairment, etc …

[HTML][HTML] Reduced electron transport chain complex I protein abundance and function in Mfn2-deficient myogenic progenitors lead to oxidative stress and mitochondria …

N Luo, F Yue, Z Jia, J Chen, Q Deng… - … : official publication of …, 2021 - ncbi.nlm.nih.gov
Mitochondrial remodeling through fusion and fission is crucial for progenitor cell
differentiation but its role in myogenesis is poorly understood. Here, we characterized the …

Sugt1 loss in skeletal muscle stem cells impairs muscle regeneration and causes premature muscle aging

Z He, X Chen, G Liu, Y Li, F Yang, H Sun… - Life Medicine, 2023 - academic.oup.com
Adult skeletal muscle stem cells (MuSCs) are essential for muscle homeostasis and
regeneration. During aging, the number of MuSCs and their regenerative capacity gradually …

Isolation, culture, and differentiation of primary myoblasts derived from muscle satellite cells

KH Kim, J Qiu, S Kuang - Bio-protocol, 2020 - bio-protocol.org
The skeletal muscle is key for body mobility and motor performance, but aging and diseases
often lead to progressive loss of muscle mass due to wasting or degeneration of muscle …

Parasympathetic-macrophages-ductal epithelial cells axis promotes female rat submandibular gland regeneration after excretory duct ligation/deligation

B Wang, D Li, J Li, W An, Z Li, Q Shao, L Qin - Archives of Oral Biology, 2023 - Elsevier
Objective Submandibular gland (SMG) regeneration depends on parasympathetic signals
that modulate this process primarily by promoting ductal epithelial cell proliferation. The …

Attenuated cell-cycle division protein 2 and elevated mitotic roles of polo-like kinase 1 characterize deficient myoblast fusion in peripheral arterial disease

R Ferrari, G Cong, A Chattopadhyay, B Xie… - Biochemical and …, 2022 - Elsevier
Abstract Introduction We propose that MuSC-derived myoblasts in PAD have transcriptomic
differences that can highlight underlying causes of ischemia-induced myopathy. Methods …