Methods and compositions for immunomodulation

J Mata-Fink, J Round, NB Afeyan… - US Patent 10,869,898, 2020 - Google Patents
2020-08-19 Assigned to FLAGSHIP PIONEERING, INC. reassignment FLAGSHIP
PIONEERING, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …

Protein modification of living cells using sortase

LK Swee, HL Ploegh - US Patent 10,260,038, 2019 - Google Patents
2015-11-19 Assigned to WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
reassignment WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH ASSIGNMENT OF …

Protein modification of living cells using sortase

LK Swee, HL Ploegh - US Patent 11,492,590, 2022 - Google Patents
Non-genetically engineered mammalian cells modified by sortase-mediated conjugation of
an agent thereto are provided. Methods of conjugating agents to non-genetically engineered …

In vitro production of red blood cells with proteins comprising sortase recognition motifs

H Lodish, HL Ploegh, HY Lee, J Shi, L Hoffman… - US Patent …, 2019 - Google Patents
Methods for the in vitro production of enucleated red blood cells and the enucleated red
blood cells thus prepared are provided. Such enucleated red blood cells may express a …

Compositions and methods related to engineered erythoid cells comprising 4-1BBL

A Kahvejian, J Mata-Fink, RJ Deans, TF Chen… - US Patent …, 2019 - Google Patents
The invention includes compositions and methods related to multimodal therapies, eg, for
treating a cancer. A multimodal therapy described herein provides and/or administers a …

Synthetic membrane-receiver complexes

A Kahvejian, J Mata-Fink, J Round, DA Berry… - US Patent …, 2019 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52293163&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Using sortases to install click chemistry handles for protein ligation

HL Ploegh, MD Witte, NC Yoder - US Patent 11,028,185, 2021 - Google Patents
2019-07-22 Assigned to WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
reassignment WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH ASSIGNMENT OF …

Synthetic membrane-receiver complexes

A Kahvejian, J Mata-Fink, J Round, DA Berry… - US Patent …, 2019 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52293163&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Synthetic membrane-receiver complexes

A Kahvejian, J Mata-Fink, J Round, DA Berry… - US Patent …, 2019 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52293163&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

18F labeling of proteins using sortases

M Rashidian, HL Ploegh, R Weissleder… - US Patent …, 2020 - Google Patents
2016-06-14 Assigned to WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
reassignment WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH ASSIGNMENT OF …