Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

GluN3-containing NMDA receptors (GluN3-NMDARs) are rarer than the'classical'NMDARs,
which are composed solely of GluN1 and GluN2 subunits, and have non-conventional …

Cognitive dysfunction is one of the most typical characteristics in various neurodegenerative
diseases such as Alzheimer's disease and Parkinson's disease (advanced stage). Although …

NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major
component of excitatory neurotransmission in the central nervous system (CNS). They are …

Various combinations of subunits assemble to form the NMDA-type glutamate receptor
(NMDAR), generating diversity in its functions. Here we review roles of the unique NMDAR …

The two GluN3 subunits were the last NMDA receptor subunits to be cloned some 15 years
ago. Strikingly, despite the steadily growing interest in their function, their physiological role …

Foxa1 and Foxa2 play both redundant and distinct roles in early pancreas development. We
demonstrate here that inducible ablation of both transcription factors in mature mouse β …

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system.
There are three distinct subtypes of ionotropic glutamate receptors (GluRs) that have been …

Background In addition to their original applications to lowering cholesterol, statins display
multiple neuroprotective effects. N-methyl-D-aspartate (NMDA) receptors interact closely …

Non‐conventional N‐methyl‐d‐aspartate receptors (NMDARs) containing GluN3A subunits
have unique biophysical, signalling and localization properties within the NMDAR family …