Emerging role of carbonic anhydrase inhibitors

CT Supuran - Clinical Science, 2021 - portlandpress.com
Inhibition of carbonic anhydrase (CA, EC 4.2. 1.1) was clinically exploited for decades, as
most modern diuretics were obtained considering as lead molecule acetazolamide, the …

Engineered living materials: prospects and challenges for using biological systems to direct the assembly of smart materials

PQ Nguyen, NMD Courchesne… - Advanced …, 2018 - Wiley Online Library
Vast potential exists for the development of novel, engineered platforms that manipulate
biology for the production of programmed advanced materials. Such systems would possess …

A stony coral cell atlas illuminates the molecular and cellular basis of coral symbiosis, calcification, and immunity

S Levy, A Elek, X Grau-Bové, S Menéndez-Bravo… - Cell, 2021 - cell.com
Stony corals are colonial cnidarians that sustain the most biodiverse marine ecosystems on
Earth: coral reefs. Despite their ecological importance, little is known about the cell types …

A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation

CT Supuran - Bioorganic & Medicinal Chemistry Letters, 2023 - Elsevier
Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …

Antioxidant and anticholinergic properties of olivetol

P Taslimi, İ Gulçin - Journal of food biochemistry, 2018 - Wiley Online Library
Olivetol is a pioneer in diverse syntheses of tetrahydrocannabinol. It is produced by a type of
insects, which is used as a pheromone, antiseptic, or repellent agent. In this study, we …

Geochemical negative emissions technologies: Part I. Review

JS Campbell, S Foteinis, V Furey, O Hawrot… - Frontiers in …, 2022 - frontiersin.org
Over the previous two decades, a diverse array of geochemical negative emissions
technologies (NETs) have been proposed, which use alkaline minerals for removing and …

Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase

A Nocentini, A Angeli, F Carta, JY Winum… - Journal of Enzyme …, 2021 - Taylor & Francis
Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) generally
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …

Coral host cells acidify symbiotic algal microenvironment to promote photosynthesis

KL Barott, AA Venn, SO Perez… - Proceedings of the …, 2015 - National Acad Sciences
Symbiotic dinoflagellate algae residing inside coral tissues supply the host with the majority
of their energy requirements through the translocation of photosynthetically fixed carbon …

Comparative genomics explains the evolutionary success of reef-forming corals

D Bhattacharya, S Agrawal, M Aranda, S Baumgarten… - elife, 2016 - elifesciences.org
Transcriptome and genome data from twenty stony coral species and a selection of
reference bilaterians were studied to elucidate coral evolutionary history. We identified …

Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors

G De Simone, V Alterio, CT Supuran - Expert opinion on drug …, 2013 - Taylor & Francis
Introduction: Carbonic anhydrases (CAs, EC 4.2. 1.1) exist as five genetically distinct
families (α, β, γ, δ and ζ) in organisms all over the phylogenetic tree. Due to the ubiquity of …