Making and shaping endochondral and intramembranous bones

GL Galea, MR Zein, S Allen… - Developmental …, 2021 - Wiley Online Library
Skeletal elements have a diverse range of shapes and sizes specialized to their various
roles including protecting internal organs, locomotion, feeding, hearing, and vocalization …

Genetics of the phenotypic evolution in sheep: a molecular look at diversity-driving genes

P Kalds, S Zhou, Y Gao, B Cai, S Huang… - Genetics Selection …, 2022 - Springer
Background After domestication, the evolution of phenotypically-varied sheep breeds has
generated rich biodiversity. This wide phenotypic variation arises as a result of hidden …

Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits

L Chen, Q Qiu, YU Jiang, K Wang, Z Lin, Z Li, F Bibi… - Science, 2019 - science.org
INTRODUCTION The ruminants are one of the most successful mammalian lineages,
exhibiting extensive morphological and ecological diversity and containing several key …

Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor

Z Liu, W Li, L Geng, L Sun, Q Wang, Y Yu, P Yan… - Cell discovery, 2022 - nature.com
Regenerative capacity declines throughout evolution and with age. In this study, we asked
whether metabolic programs underlying regenerative capability might be conserved across …

A population of stem cells with strong regenerative potential discovered in deer antlers

T Qin, G Zhang, Y Zheng, S Li, Y Yuan, Q Li, M Hu, H Si… - Science, 2023 - science.org
The annual regrowth of deer antlers provides a valuable model for studying organ
regeneration in mammals. We describe a single-cell atlas of antler regrowth. The earliest …

Deer antlers: the fastest growing tissue with least cancer occurrence

C Li, Y Li, W Wang, M Scimeca, G Melino… - Cell Death & …, 2023 - nature.com
Deer antlers are a bony organ solely able to acquired distinct unique attributes during
evolution and all these attributes are against thus far known natural rules. One of them is as …

Molecular mechanisms and topological consequences of drastic chromosomal rearrangements of muntjac deer

Y Yin, H Fan, B Zhou, Y Hu, G Fan, J Wang… - Nature …, 2021 - nature.com
Muntjac deer have experienced drastic karyotype changes during their speciation, making it
an ideal model for studying mechanisms and functional consequences of mammalian …

Seadragon genome analysis provides insights into its phenotype and sex determination locus

M Qu, Y Liu, Y Zhang, S Wan, V Ravi, G Qin… - Science …, 2021 - science.org
The iconic phenotype of seadragons includes leaf-like appendages, a toothless tubular
mouth, and male pregnancy involving incubation of fertilized eggs on an open “brood patch.” …

Antlers-evolution, development, structure, composition, and biomechanics of an outstanding type of bone

T Landete-Castillejos, H Kierdorf, S Gomez, S Luna… - Bone, 2019 - Elsevier
Antlers are bony appendages of deer that undergo periodic regeneration from the top of
permanent outgrowths (the pedicles) of the frontal bones. Of the “less familiar” bone types …

Exosomes in osteoarthritis: Updated insights on pathogenesis, diagnosis, and treatment

WJ Fan, D Liu, LY Pan, WY Wang, YL Ding… - Frontiers in Cell and …, 2022 - frontiersin.org
Osteoarthritis (OA) has remained a prevalent public health problem worldwide over the past
decades. OA is a global challenge because its specific pathogenesis is unclear, and no …