Peptoids and polypeptoids at the frontier of supra-and macromolecular engineering

N Gangloff, J Ulbricht, T Lorson, H Schlaad… - Chemical …, 2016 - ACS Publications
In most general terms, polymers and their supramolecular assemblies have been defining
life on this planet since its conception. Polymers of nucleic acids carry the code of life and …

Polysarcosine-containing copolymers: Synthesis, characterization, self-assembly, and applications

A Birke, J Ling, M Barz - Progress in Polymer Science, 2018 - Elsevier
Although the first polysarcosine (pSar) synthesis by Wesseley et al. was reported almost a
century ago, it was only recently that pSar gained broader attention and is considered a …

Peptoid polymers: a highly designable bioinspired material

J Sun, RN Zuckermann - ACS nano, 2013 - ACS Publications
Bioinspired polymeric materials are attracting increasing attention due to significant
advantages over their natural counterparts: the ability to precisely tune their structures over a …

Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides

NP Chongsiriwatana, JA Patch… - Proceedings of the …, 2008 - National Acad Sciences
Antimicrobial peptides (AMPs) and their mimics are emerging as promising antibiotic agents.
We present a library of “ampetoids”(antimicrobial peptoid oligomers) with helical structures …

Recent progress in the design of monodisperse, sequence‐defined macromolecules

SC Solleder, RV Schneider, KS Wetzel… - Macromolecular …, 2017 - Wiley Online Library
This review describes different synthetic strategies towards sequence‐defined,
monodisperse macromolecules, which are built up by iterative approaches and lead to …

Sequence programmable peptoid polymers for diverse materials applications

AS Knight, EY Zhou, MB Francis… - Advanced …, 2015 - Wiley Online Library
Polymer sequence programmability is required for the diverse structures and complex
properties that are achieved by native biological polymers, but efforts towards controlling the …

Peptoid origins

RN Zuckermann - Peptide Science, 2011 - Wiley Online Library
Peptoid oligomers were initially developed as part of a larger basic research effort to
accelerate the drug‐discovery process in the biotech/biopharma industry. Their ease of …

Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α-Peptoids) and Derivatives

AS Culf, RJ Ouellette - Molecules, 2010 - mdpi.com
Peptoids (N-substituted polyglycines and extended peptoids with variant backbone amino-
acid monomer units) are oligomeric synthetic polymers that are becoming a valuable …

Iterative Synthesis of Stereo‐ and Sequence‐Defined Polymers via Acid‐Orthogonal Deprotection Chemistry

W He, S Wang, M Li, X Wang, Y Tao - Angewandte Chemie, 2022 - Wiley Online Library
Absolute control over polymer stereo‐and sequence structure is highly challenging in
polymer chemistry. Here, an acid‐orthogonal deprotection strategy is proposed for the …

Biomimetic nanostructures: Creating a high-affinity zinc-binding site in a folded nonbiological polymer

BC Lee, TK Chu, KA Dill… - Journal of the American …, 2008 - ACS Publications
One of the long-term goals in developing advanced biomaterials is to generate protein-like
nanostructures and functions from a completely nonnatural polymer. Toward that end, we …