Epigenetic pathways play a pivotal role in the development and function of the immune
system. Over the last decade, a growing body of studies has been published out seeking to …

Rheumatoid arthritis (RA) is a systemic autoimmune disease. Synovial hyperplasia and
persistent inflammation serve as its typical pathological manifestations, which ultimately lead …

Macrophages are crucially involved in the pathogenesis of rheumatoid arthritis (RA).
Macrophages of the M1 phenotype act as pro-inflammatory mediators in synovium, whereas …

Ageing is characterized by a progressive loss of cellular function that leads to a decline in
tissue homeostasis, increased vulnerability and adverse health outcomes. Important …

The aim of the present study was to determine the effects of curcumin on the
osteoclastogenic potential of peripheral blood mononuclear cells (PBMCs) obtained from …

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by symmetrical
polyarthritis as its main clinical manifestation. Uncontrolled RA eventually leads to joint …

One of the problems of modern medical science is cardiovascular pathology caused by
atherosclerotic vascular lesions in patients with autoimmune rheumatic diseases (ARDs) …

Tuberculosis (TB) is the leading cause of death from a single infectious agent. The estimated
total global TB deaths in 2019 were 1.4 million. The decline in TB incidence rate is very …

IL-23, which is composed of p19 and p40 subunits, is a proinflammatory cytokine that
contributes to the formation and maintenance of Th17 cells in inflammatory autoimmune …

Objective We analyzed NAD+ metabolism in patients with rheumatoid arthritis (RA), its
association with disease activity and clinical outcomes of RA, and the therapeutic potential …