The intercellular communication that regulates cell fate during animal development must be
precisely controlled to avoid dangerous errors. How is this achieved? Recent work has …

The positioning and elaboration of ectodermal veins in the wing of Drosophila melanogaster
rely on widely utilized developmental signals, including those mediated by EGF, BMP …

The Drosophila eye has contributed much to our knowledge of cell differentiation. This
understanding has primarily come from the study of the R7 photoreceptor; much less is …

Sprouty (Spry) inhibits signalling by receptor tyrosine kinases; however, the molecular
mechanism underlying this function has not been defined. Here we show that after …

Antagonists of several growth factor signaling pathways play important roles in
developmental patterning by limiting the range of the cognate inducer. Here, we describe an …

In Drosophila wing imaginal discs, the Wingless (Wg) protein acts as a morphogen,
emanating from the dorsal/ventral (D/V) boundary of the disc to directly define cell identities …

Embryonic development is an emergent process in which increasing complexity is
generated by sequential cellular interactions. Recently, it has become clear that such …

Summary EGFR-RAS-ERK signaling promotes growth and proliferation in many cell types,
and genetic hyperactivation of RAS-ERK signaling drives many cancers. Yet, despite …

Signaling cascades triggered by receptor tyrosine kinases (RTKs) participate in diverse
developmental processes. The active state of these signaling pathways was monitored by …

Exploring the role of phase separation in intracellular compartment formation is an active
area of research. However, the associations of phase separation with intestinal stem cell …