An Updated Review on the Multifaceted Therapeutic Potential of Calendula officinalis L.

K Shahane, M Kshirsagar, S Tambe, D Jain, S Rout… - Pharmaceuticals, 2023 - mdpi.com
Calendula officinalis Linn.(CO) is a popular medicinal plant from the plant kingdom's
Asteraceae family that has been used for millennia. This plant contains flavonoids …

Cyanobacterial metabolites as novel drug candidates in corona viral therapies: A review

S Prabhu, S Vijayakumar, P Praseetha - Chronic Diseases and …, 2022 - mednexus.org
Most of the medical and nonmedical research labs, all around the world, are racing against
time to produce an effective vaccine or an antiviral medicine for coronavirus disease 2019 …

Galantamine based novel acetylcholinesterase enzyme inhibitors: A molecular modeling design approach

LB Silva, EFB Ferreira, Maryam, JM Espejo-Román… - Molecules, 2023 - mdpi.com
Acetylcholinesterase (AChE) enzymes play an essential role in the development of
Alzheimer's disease (AD). Its excessive activity causes several neuronal problems …

Identification of a novel dual inhibitor of acetylcholinesterase and butyrylcholinesterase: in vitro and in silico studies

RBM de Almeida, DB Barbosa, MR do Bomfim… - Pharmaceuticals, 2023 - mdpi.com
The enhancement of cholinergic functions via acetylcholinesterase (AChE) and
butyrylcholinesterase (BuChE) inhibition is considered a valuable therapeutic strategy for …

Synthesis of new hydrazones using a biodegradable catalyst, their biological evaluations and molecular modeling studies (Part-II)

SN Mali, A Pandey - Journal of Computational Biophysics and …, 2022 - World Scientific
Hydrazones typically have an azomethine '–NHN= CH group'which is crucial for varieties of
pharmacological activities. In this study, we have synthesized a set of 15 new hydrazones …

Alkaloid from Geissospermum sericeum Benth. & Hook.f. ex Miers (Apocynaceae) Induce Apoptosis by Caspase Pathway in Human Gastric Cancer Cells

ML Carmo Bastos, JV Silva-Silva, J Neves Cruz… - Pharmaceuticals, 2023 - mdpi.com
Gastric cancer is among the major causes of death from neoplasia leading causes of death
worldwide, with high incidence rates and problems related to its treatment. Here, we outline …

Extraction Yield, Chemical Composition, Preliminary Toxicity of Bignonia nocturna (Bignoniaceae) Essential Oil and in Silico Evaluation of the Interaction

M Santana de Oliveira… - Chemistry & …, 2021 - Wiley Online Library
Bignonia nocturna (Bignoniaceae) is a plant used for medicinal purposes by the Amazonian
indigenous peoples. To date, there have been no reported studies on its toxicity. The …

Balanced QSAR and molecular modeling to identify structural requirements of imidazopyridine analogues as anti-infective agents against trypanosomiases

SN Mali, A Pandey - Journal of Computational Biophysics and …, 2022 - World Scientific
Human African trypanosomiasis (HAT), a fatal infection caused by Trypanosoma brucei (T.
brucei) is considered as a neglected disease in the tropical areas, and newer agents with …

Novel chalcones derivatives with potential antineoplastic activity investigated by docking and molecular dynamics simulations

RAM Neto, CBR Santos, SVC Henriques… - Journal of …, 2022 - Taylor & Francis
Glioblastoma is an aggressive primary tumor of the central nervous system (CNS). Is the
most aggressive among infiltrative gliomas arising from the CNS. This tumor has low patient …

[HTML][HTML] Evaluation of the genotoxicity and mutagenicity of isoeleutherin and eleutherin isolated from Eleutherine plicata herb. using bioassays and in silico …

ALG Castro, JN Cruz, DF Sodré… - Arabian Journal of …, 2021 - Elsevier
The biological activities of Eleutherine plicata Herb. have been linked to isoeleutherin and
eleutherin naphthoquinones. However, there are few reports in the literature regarding the …