The transactivation domain of the cAMP response element-binding protein (CREB) consists
of two major domains. The glutamine-rich Q2 domain, which interacts with the general …

The prognostication of head and neck squamous cell carcinoma (HNSCC) is largely based
upon the tumor size and location and the presence of lymph node metastases. Here we …

Human papillomavirus (HPV) is associated with a subset of head and neck squamous cell
carcinoma (HNSCC). Between 15% and 35% of HNSCCs harbor HPV DNA. Demographic …

Homeobox transcription factors are key intrinsic regulators of myogenesis. In studies
spanning several years, we have characterized the homeobox factor Barx2 as a novel …

Previously, we reported an ability of NE to promote processes of plasticity in neuroblastoma
cells, as observed by morphological changes such as an elongated granule-rich cell body …

Barx1 modulates cellular adhesion molecule expression and participates in specification of
tooth-types, but little is understood of its role in patterning the pharyngeal arches. We …

Among the many factors involved in regulation of chondrogenesis, bone morphogenetic
proteins (BMPs) and members of the Sox and homeobox transcription factor families have …

The human homeobox BARX2 is located at 11q24-q25, within a minimal region associated
with frequent loss of heterozygosity and adverse survival in epithelial ovarian cancer …

The canonical Wnt signaling pathway is critical for myogenesis and can induce muscle
progenitors to switch from proliferation to differentiation; how Wnt signals integrate with …

Muscle growth and regeneration are regulated through a series of spatiotemporally
dependent signaling and transcriptional cascades. Although the transcriptional program …