Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Cancer initiation and proliferation is regulated by both epigenetic and genetic events with
epigenetic modifications being increasingly identified as important targets for cancer …

Cancer is the second leading cause of death in US. Despite the emergence of new, targeted
agents, and the use of various therapeutic combinations, none of the available treatment …

Myelodysplastic syndromes are clonal marrow stem-cell disorders, characterised by
ineffective haemopoiesis leading to blood cytopenias, and by progression to acute myeloid …

Rheumatoid arthritis (RA) is a long-term autoimmune disease of unknown etiology that leads
to progressive joint destruction and ultimately to disability. RA affects as much as 1% of the …

Myelodysplastic syndrome (MDS) is a heterogeneous, clonal hematological disorder
characterized by ineffective hematopoiesis, cytopenia, morphologic dysplasia, and …

DNA methylation and histone modification are epigenetic mechanisms that result in altered
gene expression and cellular phenotype. The exact role of methylation in myelodysplastic …

Aging has been recognized to be a highly complex biological health problem with a high risk
of chronic diseases, including type 2 diabetes, atherosclerosis, chronic bronchitis or …

Anemia is characteristic of myelodysplastic syndromes (MDS). The mechanisms of anemia
in MDS are unclear. Using a mouse genetic approach, here we show that dual deficiency of …

Abstract Treatment with azacitidine (AZA), a demethylating agent, prolonged overall survival
(OS) vs conventional care in patients with higher-risk myelodysplastic syndromes (MDS). As …