Despite scientific discoveries in the field of gene and cell therapy, some diseases still have
no effective treatment. Advances in genetic engineering methods have enabled the …

The objective of this manuscript is to provide quantitative insights into the tissue distribution
of nanoparticles. Published pharmacokinetics of nanoparticles in plasma, tumor and 13 …

In recent years, gene therapy has made remarkable achievements in tumor treatment. In a
successfully cancer gene therapy, a smart gene delivery system is necessary for both …

Salivary gland (SG) dysfunction, due to radiotherapy, disease, or aging, is a clinical
manifestation that has the potential to cause severe oral and/or systemic diseases and …

Given the recent success of gene therapy modalities and the growing number of cell and
gene-based therapies in clinical development across many different therapeutic areas, it is …

Deciphering the crosstalk between RNA-binding proteins and corresponding RNAs will
provide a better understanding of gastric cancer (GC) progression. The comprehensive …

The use of adeno-associated virus (AAV) as a gene delivery vehicle for secreted peptide
therapeutics can enable a new approach to durably manage chronic protein insufficiencies …

Adeno-associated viruses (AAV) are important vectors for gene therapy, and accordingly,
many aspects of their cell transduction pathway have been well characterized. However, the …

Amyotrophic lateral sclerosis (ALS) is a devastating and incurable neurodegenerative
disease characterized by the progressive loss of upper and lower motor neurons. ALS …

With more than 90 approved drugs by 2020, therapeutic antibodies have played a central
role in shifting the treatment landscape of many diseases, including autoimmune disorders …