Various AAV serotypes and their applications in gene therapy: an overview
SS Issa, AA Shaimardanova, VV Solovyeva… - Cells, 2023 - mdpi.com
Despite scientific discoveries in the field of gene and cell therapy, some diseases still have
no effective treatment. Advances in genetic engineering methods have enabled the …
no effective treatment. Advances in genetic engineering methods have enabled the …
[HTML][HTML] Nanoparticle biodistribution coefficients: A quantitative approach for understanding the tissue distribution of nanoparticles
The objective of this manuscript is to provide quantitative insights into the tissue distribution
of nanoparticles. Published pharmacokinetics of nanoparticles in plasma, tumor and 13 …
of nanoparticles. Published pharmacokinetics of nanoparticles in plasma, tumor and 13 …
Biocompatible iron oxide nanoparticles for targeted cancer gene therapy: A review
J Zhang, T Zhang, J Gao - Nanomaterials, 2022 - mdpi.com
In recent years, gene therapy has made remarkable achievements in tumor treatment. In a
successfully cancer gene therapy, a smart gene delivery system is necessary for both …
successfully cancer gene therapy, a smart gene delivery system is necessary for both …
Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration
M Marinkovic, ON Tran, H Wang… - International Journal of …, 2023 - nature.com
Salivary gland (SG) dysfunction, due to radiotherapy, disease, or aging, is a clinical
manifestation that has the potential to cause severe oral and/or systemic diseases and …
manifestation that has the potential to cause severe oral and/or systemic diseases and …
The perspective of DMPK on recombinant adeno-associated virus-based gene therapy: past learning, current support, and future contribution
N Chen, K Sun, NV Chemuturi, H Cho, CQ Xia - The AAPS Journal, 2022 - Springer
Given the recent success of gene therapy modalities and the growing number of cell and
gene-based therapies in clinical development across many different therapeutic areas, it is …
gene-based therapies in clinical development across many different therapeutic areas, it is …
CPEB3 suppresses gastric cancer progression by inhibiting ADAR1-mediated RNA editing via localizing ADAR1 mRNA to P bodies
J Chen, L Li, TY Liu, HF Fu, YH Lai, X Lei, JF Xu, JS Yu… - Oncogene, 2022 - nature.com
Deciphering the crosstalk between RNA-binding proteins and corresponding RNAs will
provide a better understanding of gastric cancer (GC) progression. The comprehensive …
provide a better understanding of gastric cancer (GC) progression. The comprehensive …
Allometric-like scaling of AAV gene therapy for systemic protein delivery
The use of adeno-associated virus (AAV) as a gene delivery vehicle for secreted peptide
therapeutics can enable a new approach to durably manage chronic protein insufficiencies …
therapeutics can enable a new approach to durably manage chronic protein insufficiencies …
Structural characterization of porcine adeno-associated virus capsid protein with nuclear trafficking protein importin alpha reveals a bipartite nuclear localization signal
Adeno-associated viruses (AAV) are important vectors for gene therapy, and accordingly,
many aspects of their cell transduction pathway have been well characterized. However, the …
many aspects of their cell transduction pathway have been well characterized. However, the …
Prospects for gene replacement therapies in amyotrophic lateral sclerosis
I Giovannelli, A Higginbottom, J Kirby… - Nature Reviews …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a devastating and incurable neurodegenerative
disease characterized by the progressive loss of upper and lower motor neurons. ALS …
disease characterized by the progressive loss of upper and lower motor neurons. ALS …
Modeling pharmacokinetics and pharmacodynamics of therapeutic antibodies: progress, challenges, and future directions
Y Tang, Y Cao - Pharmaceutics, 2021 - mdpi.com
With more than 90 approved drugs by 2020, therapeutic antibodies have played a central
role in shifting the treatment landscape of many diseases, including autoimmune disorders …
role in shifting the treatment landscape of many diseases, including autoimmune disorders …