Computational Approaches to Predict Protein–Protein Interactions in Crowded Cellular Environments

G Grassmann, M Miotto, F Desantis… - Chemical …, 2024 - ACS Publications
Investigating protein–protein interactions is crucial for understanding cellular biological
processes because proteins often function within molecular complexes rather than in …

Bioorthogonal Chemistry in Cellular Organelles

V Šlachtová, M Chovanec, M Rahm… - Topics in Current …, 2024 - Springer
While bioorthogonal reactions are routinely employed in living cells and organisms, their
application within individual organelles remains limited. In this review, we highlight diverse …

From Monomers to Hexamers: A Theoretical Probability of the Neighbor Density Approach to Dissect Protein Oligomerization in Cells

H Chen, TY Chen - Analytical Chemistry, 2023 - ACS Publications
Deciphering the oligomeric state of proteins within cells is pivotal to understanding their role
in intricate cellular processes. With the recent advances in single-molecule localization …

From Molecules to Classrooms: A Comprehensive Guide to Single-Molecule Localization Microscopy

G Yan, Y Zhang, A Allamprese, KN Brooks… - Journal of Chemical …, 2024 - ACS Publications
Single-molecule localization microscopy (SMLM) has revolutionized our ability to visualize
cellular structures, offering unprecedented detail. However, the intricate biophysical …

Advancements and Practical Considerations for Biophysical Research: Navigating the Challenges and Future of Super-resolution Microscopy

H Chen, G Yan, MH Wen, KN Brooks… - … & Biomedical Imaging, 2024 - ACS Publications
The introduction of super-resolution microscopy (SRM) has significantly advanced our
understanding of cellular and molecular dynamics, offering a detailed view previously …