[HTML][HTML] Mitochondrial sirtuins, metabolism, and aging
Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …
NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus
NAD+ has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and
maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded …
maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded …
Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility
C Tatone, G Di Emidio, A Barbonetti… - Human …, 2018 - academic.oup.com
Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …
that catalyze post-translational modifications of proteins. Together, they respond to …
SIRT5 desuccinylates and activates pyruvate kinase M2 to block macrophage IL-1β production and to prevent DSS-induced colitis in mice
LPS-activated macrophages undergo a metabolic shift from dependence on mitochondria-
produced ATP to reliance on aerobic glycolysis, where PKM2 is a critical determinant. Here …
produced ATP to reliance on aerobic glycolysis, where PKM2 is a critical determinant. Here …
Role of nicotinamide adenine dinucleotide and related precursors as therapeutic targets for age-related degenerative diseases: rationale, biochemistry …
Significance: Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide
that serves as an essential cofactor and substrate for a number of critical cellular processes …
that serves as an essential cofactor and substrate for a number of critical cellular processes …
Protein acetylation in metabolism—metabolites and cofactors
KJ Menzies, H Zhang, E Katsyuba… - Nature Reviews …, 2016 - nature.com
Reversible acetylation was initially described as an epigenetic mechanism regulating DNA
accessibility. Since then, this process has emerged as a controller of histone and nonhistone …
accessibility. Since then, this process has emerged as a controller of histone and nonhistone …
Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function
Cellular metabolites, such as acyl-CoA, can modify proteins, leading to protein
posttranslational modifications (PTMs). One such PTM is lysine succinylation, which is …
posttranslational modifications (PTMs). One such PTM is lysine succinylation, which is …
Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology
S Kumar, DB Lombard - Critical reviews in biochemistry and …, 2018 - Taylor & Francis
Sirtuins are NAD+-dependent protein deacylases/ADP-ribosyltransferases that have
emerged as candidate targets for new therapeutics to treat metabolic disorders and other …
emerged as candidate targets for new therapeutics to treat metabolic disorders and other …
Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases
GR Wagner, MD Hirschey - Molecular cell, 2014 - cell.com
Cellular proteins are decorated with a wide range of acetyl and other acyl modifications.
Many studies have demonstrated regulation of site-specific acetylation by acetyltransferases …
Many studies have demonstrated regulation of site-specific acetylation by acetyltransferases …
SIRT5 regulation of ammonia-induced autophagy and mitophagy
L Polletta, E Vernucci, I Carnevale, T Arcangeli… - Autophagy, 2015 - Taylor & Francis
In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1,
the first enzyme of the urea cycle. However, while SIRT5 is ubiquitously expressed, urea …
the first enzyme of the urea cycle. However, while SIRT5 is ubiquitously expressed, urea …