[HTML][HTML] Mitochondrial sirtuins, metabolism, and aging

Z Ji, GH Liu, J Qu - Journal of Genetics and Genomics, 2022 - Elsevier
Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …

NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus

C Cantó, KJ Menzies, J Auwerx - Cell metabolism, 2015 - cell.com
NAD+ has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and
maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded …

Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility

C Tatone, G Di Emidio, A Barbonetti… - Human …, 2018 - academic.oup.com
Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …

SIRT5 desuccinylates and activates pyruvate kinase M2 to block macrophage IL-1β production and to prevent DSS-induced colitis in mice

F Wang, K Wang, W Xu, S Zhao, D Ye, Y Wang, Y Xu… - Cell reports, 2017 - cell.com
LPS-activated macrophages undergo a metabolic shift from dependence on mitochondria-
produced ATP to reliance on aerobic glycolysis, where PKM2 is a critical determinant. Here …

Role of nicotinamide adenine dinucleotide and related precursors as therapeutic targets for age-related degenerative diseases: rationale, biochemistry …

N Braidy, J Berg, J Clement, F Khorshidi… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide
that serves as an essential cofactor and substrate for a number of critical cellular processes …

Protein acetylation in metabolism—metabolites and cofactors

KJ Menzies, H Zhang, E Katsyuba… - Nature Reviews …, 2016 - nature.com
Reversible acetylation was initially described as an epigenetic mechanism regulating DNA
accessibility. Since then, this process has emerged as a controller of histone and nonhistone …

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

S Sadhukhan, X Liu, D Ryu… - Proceedings of the …, 2016 - National Acad Sciences
Cellular metabolites, such as acyl-CoA, can modify proteins, leading to protein
posttranslational modifications (PTMs). One such PTM is lysine succinylation, which is …

Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology

S Kumar, DB Lombard - Critical reviews in biochemistry and …, 2018 - Taylor & Francis
Sirtuins are NAD+-dependent protein deacylases/ADP-ribosyltransferases that have
emerged as candidate targets for new therapeutics to treat metabolic disorders and other …

Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases

GR Wagner, MD Hirschey - Molecular cell, 2014 - cell.com
Cellular proteins are decorated with a wide range of acetyl and other acyl modifications.
Many studies have demonstrated regulation of site-specific acetylation by acetyltransferases …

SIRT5 regulation of ammonia-induced autophagy and mitophagy

L Polletta, E Vernucci, I Carnevale, T Arcangeli… - Autophagy, 2015 - Taylor & Francis
In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1,
the first enzyme of the urea cycle. However, while SIRT5 is ubiquitously expressed, urea …