Predicting skin permeability by means of computational approaches: Reliability and caveats in pharmaceutical studies
The skin is the main barrier between the internal body environment and the external one.
The characteristics of this barrier and its properties are able to modify and affect drug …
The characteristics of this barrier and its properties are able to modify and affect drug …
In silico design, synthesis, and biological evaluation of anticancer arylsulfonamide endowed with anti-telomerase activity
G Culletta, M Allegra, AM Almerico, I Restivo… - Pharmaceuticals, 2022 - mdpi.com
Telomerase, a reverse transcriptase enzyme involved in DNA synthesis, has a tangible role
in tumor progression. Several studies have evidenced telomerase as a promising target for …
in tumor progression. Several studies have evidenced telomerase as a promising target for …
Telomere dysfunction in some pediatric congenital and growth-related diseases
B Zheng, J Fu - Frontiers in Pediatrics, 2023 - frontiersin.org
Telomere wear and dysfunction may lead to aging-related diseases. Moreover, increasing
evidence show that the occurrence, development, and prognosis of some pediatric diseases …
evidence show that the occurrence, development, and prognosis of some pediatric diseases …
Targeting nonsense: optimization of 1, 2, 4-oxadiazole trids to rescue cftr expression and functionality in cystic fibrosis cell model systems
Cystic fibrosis (CF) patients develop a severe form of the disease when the cystic fibrosis
transmembrane conductance regulator (CFTR) gene is affected by nonsense mutations …
transmembrane conductance regulator (CFTR) gene is affected by nonsense mutations …
New 1,3,4‒oxadiazole Quinazolines as Potential Anticancer Agents: Design, Synthesis, Biological Evaluation, and In silico Studies
V Gujja, K Sadineni, SK Koppula… - Current Drug …, 2025 - benthamdirect.com
Background A novel series of 1, 3, 4‒oxadiazole connected to derivatives of quinazolinone
(7a–e and 8a–f) was synthesized in the current investigation, and its anticancer and …
(7a–e and 8a–f) was synthesized in the current investigation, and its anticancer and …
Design, Synthesis of Flurbiprofen Based 1,3,4‐Oxadiazoles and Constrained Anticancer, Antioxidant Agents: In silico Docking Analysis
S Bhoomandla, BK Chennuri, S Sirisha… - Chemistry & … - Wiley Online Library
Flurbiprofen, a primary component of a nonsteroidal anti‐inflammatory drug (NSAID) used to
relieve symptoms of arthritis, and is a considerable interest in medicinal chemistry due to its …
relieve symptoms of arthritis, and is a considerable interest in medicinal chemistry due to its …