The extracellular matrix (ECM) is a highly complex structure through which biochemical and
mechanical signals are transmitted. In processes of cell migration, the ECM also acts as a …

Fibrin is the three-dimensional mechanical scaffold of protective blood clots that stop
bleeding and pathological thrombi that obstruct blood vessels. Fibrin must be mechanically …

Hydrostatic pressure (HP) and osmotic stress (OS) play an important role in various
biological processes, such as cell proliferation and differentiation. In contrast to canonical …

The clinical treatment of large, full-thickness skin injuries with tissue-engineered autologous
dermo–epidermal skin substitutes is an emerging alternative to split-thickness skin grafting …

The mechanical properties of the skin determine tissue function and regulate dermal cell
behavior. Yet measuring these properties remains challenging, as evidenced by the large …

Evaluating the nonlinear dynamics of human descending thoracic aortas is essential for
building the next generation of vascular prostheses. This study characterizes the nonlinear …

The mechanical stability of blood clots necessary for their functions is provided by fibrin, a
fibrous gel. Rupture of clots leads to life-threatening thrombotic embolization, which is little …

In this contribution, we propose a novel continuum mechanical concept to determine the
homogenised mechanical response of random fibre networks. Their free energy is …

Fracture toughness characterizes the ability of a material to maintain a certain level of
strength despite the presence of a macroscopic crack. Understanding this tolerance for …

The present study investigates the layer-specific mechanical behavior of human skin.
Motivated by skin's histology, a biphasic model is proposed which differentiates between …