[HTML][HTML] A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects

YX Zhou, XH Gong, H Zhang, C Peng - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Increasing pharmacological evidence supports that paeoniflorin, a water-soluble
monoterpene glycoside isolated from Paeonia lactiflora Pall.(Shaoyao in Chinese), has a …

Recent pharmaceutical evidence on the compatibility rationality of traditional Chinese medicine

M Zhou, Y Hong, X Lin, L Shen, Y Feng - Journal of Ethnopharmacology, 2017 - Elsevier
Ethnopharmacological relevance Chinese herbs have been used in China for thousands of
years and are also becoming popular in Western medicine. Formulae of traditional Chinese …

In silico studies evidenced the role of structurally diverse plant secondary metabolites in reducing SARS-CoV-2 pathogenesis

H Puttaswamy, HG Gowtham, MD Ojha, A Yadav… - Scientific reports, 2020 - nature.com
Plants are endowed with a large pool of structurally diverse small molecules known as
secondary metabolites. The present study aims to virtually screen these plant secondary …

[HTML][HTML] Paeoniflorin binds to VEGFR2 to restore autophagy and inhibit apoptosis for podocyte protection in diabetic kidney disease through PI3K-AKT signaling …

X Wang, L Jiang, X Liu, Y Huang, A Wang, H Zeng… - Phytomedicine, 2022 - Elsevier
Ethnopharmacological relevance Paeoniflorin (PF) was found to exhibit renal protection
from diabetic kidney disease (DKD) in previous trials, but its specific mechanism remains to …

Application of blanching pretreatment in herbaceous peony (Paeonia lactiflora Pall.) flower processing: Improved drying efficiency, enriched volatile profile and …

H Xu, M Wu, X Zhang, B Wang, S Wang… - Industrial Crops and …, 2022 - Elsevier
Although various techniques have been developed to dry herbaceous peony (Paeonia
lactiflora Pall.) flowers, the dried products usually have a low retention level of bioactive …

Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P‐glycoprotein

L Ye, T Wang, L Tang, W Liu, Z Yang, J Zhou… - Journal of …, 2011 - Elsevier
Andrographolide (AP), isolated from Andrographis paniculata (Burm. F.) Nees, is an
anticancer agent with significant clinical potential. This study determined its oral …

Antidiabetic potential of monoterpenes: A case of small molecules punching above their weight

S Habtemariam - International Journal of Molecular Sciences, 2017 - mdpi.com
Monoterpenes belong to the terpenoids class of natural products and are bio-synthesized
through the mevalonic acid pathway. Their small molecular weight coupled with high non …

[HTML][HTML] Preparation of paeoniflorin-glycyrrhizic acid complex transethosome gel and its preventive and therapeutic effects on melasma

Y Xiao, L Zhou, W Tao, X Yang, J Li, R Wang… - European Journal of …, 2024 - Elsevier
Paeoniflorin (PF) and glycyrrhizic acid (GL) have skin beautifying effects of anti-
inflammation, anti-oxidation, inhibition of melanin formation, and reduction of skin …

Protective effects of paeoniflorin on cardiovascular diseases: A pharmacological and mechanistic overview

X Li, C Sun, J Zhang, L Hu, Z Yu, X Zhang… - Frontiers in …, 2023 - frontiersin.org
Background and ethnopharmacological relevance: The morbidity and mortality of
cardiovascular diseases (CVDs) are among the highest of all diseases, necessitating the …

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: Optimization, characterization, and evaluation in vitro and in vivo

K Zhang, Y Zhang, Z Li, N Li, N Feng - International journal of …, 2017 - Taylor & Francis
In this study, a novel glycerosome carrier containing essential oils was prepared for topical
administration of paeoniflorin (PF) to enhance its transdermal drug delivery and improve …