Genetic associations between voltage-gated calcium channels and psychiatric disorders
Psychiatric disorders are mental, behavioral or emotional disorders. These conditions are
prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has …
prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has …
Genetic variants in major depressive disorder: from pathophysiology to therapy
In spite of promising preclinical results there is a decreasing number of new registered
medications in major depression. The main reason behind this fact is the lack of confirmation …
medications in major depression. The main reason behind this fact is the lack of confirmation …
Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with …
Antidepressants demonstrate modest response rates in the treatment of major depressive
disorder (MDD). Despite previous genome-wide association studies (GWAS) of …
disorder (MDD). Despite previous genome-wide association studies (GWAS) of …
Metabolomic signature of exposure and response to citalopram/escitalopram in depressed outpatients
Metabolomics provides valuable tools for the study of drug effects, unraveling the
mechanism of action and variation in response due to treatment. In this study we used …
mechanism of action and variation in response due to treatment. In this study we used …
Can Machine Learning help us in dealing with treatment resistant depression? A review
Background About one third of patients treated with antidepressant do not show sufficient
symptoms relief and up to 15% of patients remain symptomatic even after multiple trials are …
symptoms relief and up to 15% of patients remain symptomatic even after multiple trials are …
Pharmacogenetics in psychiatry
Mental illness represents a major health issue both at the individual and at the
socioeconomical level. This is partly due to the current suboptimal treatment options …
socioeconomical level. This is partly due to the current suboptimal treatment options …
The genetics of treatment-resistant depression: a critical review and future perspectives
Background One-third of depressed patients develop treatment-resistant depression with the
related sequelae in terms of poor functionality and worse prognosis. Solid evidence …
related sequelae in terms of poor functionality and worse prognosis. Solid evidence …
[HTML][HTML] Pharmacogenetics and depression: a critical perspective
Depression leads the higher personal and socio-economical burden within psychiatric
disorders. Despite the fact that over 40 antidepressants (ADs) are available, suboptimal …
disorders. Despite the fact that over 40 antidepressants (ADs) are available, suboptimal …
Pleiotropic genes in psychiatry: Calcium channels and the stress-related FKBP5 gene in antidepressant resistance
A candidate gene and a genome-wide approach were combined to study the
pharmacogenetics of antidepressant response and resistance. Investigated genes were …
pharmacogenetics of antidepressant response and resistance. Investigated genes were …
Targeted exome sequencing identifies five novel loci at genome-wide significance for modulating antidepressant response in patients with major depressive disorder
Z Xu, C Xie, L Xia, Y Yuan, H Zhu, X Huang, C Li… - Translational …, 2020 - nature.com
In order to determine the role of single nucleotide variants (SNVs) in modulating
antidepressant response, we conducted a study, consisting of 929 major depressive …
antidepressant response, we conducted a study, consisting of 929 major depressive …