Generating biopharmaceuticals in genetically engineered bioreactors continues to reign
supreme. Hence, genetically engineered birds have attracted considerable attention from …

Porcine β-defensin 2 (PBD-2), expressed by different tissues of pigs, is a multifunctional
cationic peptide with antimicrobial, immunomodulatory and growth-promoting abilities. As …

Bovine lactoferricin-lactoferrampin-encoding Lactobacillus reuteri (LR-LFCA) has been
found to benefit its host by strengthening its intestinal barrier. However, several questions …

Genetically modified pigs have shown considerable application potential in the fields of life
science research and livestock breeding. Nevertheless, a barrier impedes the production of …

Transgenic technology is now widely used in biomedical and agricultural fields.
Transgenesis is commonly achieved through random integration which might cause some …

Genomic Safe Harbors (GSH) are loci used for the insertion of exogenous genetic elements,
enabling exogenous gene expressing predictably without alterations of the host genome …

The genetic modification of cattle has many agricultural and biomedical applications.
However, random integration often leads to the unstable or differentially expression of the …

转基因插入位点及其侧翼序列的分子特征对转基因动物新品系培育和生物安全评价至关重要.
GHR (growth hormone receptor) 显性抑制突变体转基因猪(T274) 是本实验室前期制备的一种 …

外源基因在动物体内, 细胞内表达时, 常由于各种原因导致基因沉默. 目前, 主要有两种策略用于
打破该瓶颈: 一是利用友好位点; 二是优化外源基因顺式作用元件. 利用友好位点就是通过定点 …

Transgenic pigs play an important role in biomedicine and agriculture. The “safe harbor”
locus maintains consistent foreign gene expression in cells and is important for transgenic …