Intracellular transport is fundamental for cellular function, survival and morphogenesis.
Kinesin superfamily proteins (also known as KIFs) are important molecular motors that …

Various molecular cell biology and molecular genetic approaches have indicated significant
roles for kinesin superfamily proteins (KIFs) in intracellular transport and have shown that …

The axon is the single long fiber that extends from the neuron and transmits electrical
signals away from the cell body. The neuronal cytoskeleton, composed of microtubules …

The aim of this study was to elucidate protein-protein interactions between tegument
proteins of herpes simplex virus type 1 (HSV-1). To do so, we have cloned and expressed in …

Cytoplasmic dynein is the major molecular motor involved in minus-end-directed cellular
transport along microtubules. There is increasing evidence that the retrograde transport of …

The development and proper function of the brain requires the formation of highly complex
neuronal circuitry. These circuits are shaped from synaptic connections between neurons …

The mechanisms for delivering components to nerve terminals are diverse and highly
regulated. The diversity of kinesin motors alone is insufficient to account for the specificity of …

Mutations in the gene encoding the microtubule-severing protein spastin (spastic paraplegia
4 [SPG4]) cause hereditary spastic paraplegia (HSP), associated with neurodegeneration …

We identified a direct interaction between the neuronal transmembrane protein calsyntenin-
1 and the light chain of Kinesin-1 (KLC1). GST pulldowns demonstrated that two highly …

Within axons vital cargoes must be transported over great distances along microtubule
tracks to maintain neuronal viability. Essential to this system are the molecular motors …