Treatment of obstructive sleep apnoea (OSA) in adults is evolving, as new therapies have
been explored and introduced in clinical practice, while other approaches have been refined …

The prevalence of obstructive sleep apnea (OSA) continues to rise. So too do the health,
safety, and economic consequences. On an individual level, the causes and consequences …

People develop obstructive sleep apnoea (OSA) for different reasons. The ability to
understand these reasons, easily identify them in individual patients, and develop therapies …

Rationale: The pathophysiologic causes of obstructive sleep apnea (OSA) likely vary among
patients but have not been well characterized. Objectives: To define carefully the proportion …

Intermittent hypoxia (IH) is a hallmark manifestation of obstructive sleep apnea (OSA), a
widespread disorder of breathing. This Review focuses on the role of hypoxia-inducible …

Background Evaluation and interpretation of the literature on obstructive sleep apnea (OSA)
allows for consolidation and determination of the key factors important for clinical …

Rationale: Therapies for obstructive sleep apnea (OSA) could be administered on the basis
of a patient's own phenotypic causes (“traits”) if a clinically applicable approach were …

Historically, brief awakenings from sleep (cortical arousals) have been assumed to be vitally
important in restoring airflow and blood-gas disturbances at the end of obstructive sleep …

Rationale: A low respiratory arousal threshold (ArTH) is one of several traits involved in
obstructive sleep apnea pathogenesis and may be a therapeutic target; however, there is no …

Traditionally, the presence and severity of obstructive sleep apnea (OSA) have been defined
by the apnea–hypopnea index (AHI). Continuous positive airway pressure is generally first …