Chemokines are chemo tactic cyto kines that control the migratory patterns and positioning
of all immune cells. Although chemokines were initially appreciated as important mediators …

With the increasing use of mismatched, unrelated, and granulocyte colony-stimulating factor–
mobilized peripheral blood stem cell donor grafts and successful treatment of older …

Local environmental factors influence CD8+ T cell priming in lymph nodes (LNs). Here, we
sought to understand how factors unique to the tumor-draining mediastinal LN (mLN) impact …

Background While large-scale cancer genomic projects are comprehensively characterizing
the mutational spectrum of various cancers, so far little attention has been devoted to either …

The current study identifies CCR8+ regulatory T cells (Treg cells) as drivers of
immunosuppression. We show that in human peripheral blood cells, more than 30% of Treg …

CCR8 is a chemokine receptor expressed principally on regulatory T cells (Treg) and is
known to be critical for CCR8+ Treg-mediated immunosuppression. Recent studies have …

Highlights•A limited number of chemokines direct the polarization of CD4+ and CD8+ T
cells.•The CXCL10 is a driver chemokine of effector CD4+ and CD8+ T cells.•CXCL10 …

Abstract CD4+ regulatory T (Treg) cells, dependent upon the transcription factor Foxp3,
contribute to tumour immunosuppression but are also required for immune homeostasis …

Simple Summary The immune response against cancer is generated by effector T cells,
among them cytotoxic CD8+ T cells that destroy cancer cells and helper CD4+ T cells that …

Regulatory T (Treg) cells play a crucial role in maintaining self‐tolerance and resolution of
immune responses by employing multifaceted immunoregulatory mechanisms. However …