The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications

B Zingales, MA Miles, DA Campbell… - Infection, genetics and …, 2012 - Elsevier
The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in
nature for millions of years. The human infection, named Chagas disease, is a major public …

Current drug therapy and pharmaceutical challenges for Chagas disease

J Bermudez, C Davies, A Simonazzi, JP Real, S Palma - Acta tropica, 2016 - Elsevier
One of the most significant health problems in the American continent in terms of human
health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite …

[引用][C] Phylogeography: The History and Formation of Species

JC Avise - 2000 - books.google.com
Phylogeography is a discipline concerned with various relationships between gene
genealogies—phylogenetics—and geography. The word “phylogeography” was coined in …

Water transport in plants obeys Murray's law

KA McCulloh, JS Sperry, FR Adler - Nature, 2003 - nature.com
The optimal water transport system in plants should maximize hydraulic conductance (which
is proportional to photosynthesis,,,,) for a given investment in transport tissue. To investigate …

Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease

LA Messenger, MA Miles, C Bern - Expert review of anti-infective …, 2015 - Taylor & Francis
Over the last 30 years, concomitant with successful transnational disease control programs
across Latin America, Chagas disease has expanded from a neglected, endemic parasitic …

Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy and evolution

DA Maslov, FR Opperdoes, AY Kostygov, H Hashimi… - Parasitology, 2019 - cambridge.org
Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

Mechanism of genetic exchange in American trypanosomes

MW Gaunt, M Yeo, IA Frame, JR Stothard, HJ Carrasco… - Nature, 2003 - nature.com
The kinetoplastid Protozoa are responsible for devastating diseases. In the Americas,
Trypanosoma cruzi is the agent of Chagas' disease—a widespread disease transmissible …

Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of Chagas disease

AM Macedo, CR Machado, RP Oliveira… - Memorias do Instituto …, 2004 - SciELO Brasil
Chagas disease, caused by the protozoan Trypanosoma cruzi, has a variable clinical
course, ranging from symptomless infection to severe chronic disease with cardiovascular or …

Ancestral genomes, sex, and the population structure of Trypanosoma cruzi

JM De Freitas, L Augusto-Pinto, JR Pimenta… - PLoS …, 2006 - journals.plos.org
Acquisition of detailed knowledge of the structure and evolution of Trypanosoma cruzi
populations is essential for control of Chagas disease. We profiled 75 strains of the parasite …

Nucleotide sequences provide evidence of genetic exchange among distantly related lineages of Trypanosoma cruzi

CA Machado, FJ Ayala - Proceedings of the National …, 2001 - National Acad Sciences
Simple phylogenetic tests were applied to a large data set of nucleotide sequences from two
nuclear genes and a region of the mitochondrial genome of Trypanosoma cruzi, the agent of …