The role of serotonin (5-hydroxytryptamine; 5-HT) in the treatment of depressive and anxiety
disorders is underscored by the therapeutic action of selective 5-HT reuptake inhibitors …

The existence of an endogenous vasoconstrictor in blood serum (Stevens and Lee, 1984;
Brodie, 1900) and the presence in the gut of a substance that increases intestinal motility …

Background Pharmacological and postmortem investigations suggest that patients with
major depressive disorder have alterations in function or density of brain serotonin 1A (5-HT …

Abstract The 5‐HT1A and 5‐HT1B receptors of serotonin play important roles as auto‐and
heteroreceptors controlling the release of serotonin itself and of other neurotransmitters …

The serotoninergic system is involved in the regulation of sleep and wakefulness, its activity
being at maximum during the awake state and minimum during sleep. In particular, the …

The median (MR) and dorsal raphe (DR) nuclei contain the majority of the 5-
hydroxytryptamine (5-HT, serotonin) neurons that project to limbic forebrain regions, are …

Previous reviews have well illustrated how antidepressant treatments can differentially alter
several neurotransmitter systems in various brain areas. This review focuses on the effects …

There is considerable interest in the regulation of the extracellular compartment of the
transmitter serotonin (5-hydroxytryptamine, 5-HT) in the midbrain raphe nuclei because it …

A very important element controlling serotonin (5‐HT) release throughout the brain is the 5‐
HT1A autoreceptor present on the soma and dendrites of 5‐HT neurons since it exerts a …

Serotonin receptors 5-HT1A and 5-HT7 are highly coexpressed in brain regions implicated
in depression. However, their functional interaction has not been established. In the present …