Cell death signaling
DR Green, F Llambi - Cold Spring Harbor perspectives …, 2015 - cshperspectives.cshlp.org
In multicellular organisms, cell death is a critical and active process that maintains tissue
homeostasis and eliminates potentially harmful cells. There are three major types of …
homeostasis and eliminates potentially harmful cells. There are three major types of …
Signal transduction in cancer
R Sever, JS Brugge - Cold Spring Harbor …, 2015 - perspectivesinmedicine.cshlp.org
Cancer is driven by genetic and epigenetic alterations that allow cells to overproliferate and
escape mechanisms that normally control their survival and migration. Many of these …
escape mechanisms that normally control their survival and migration. Many of these …
[HTML][HTML] A synaptic perspective of fragile X syndrome and autism spectrum disorders
C Bagni, RS Zukin - Neuron, 2019 - cell.com
Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …
Cell signaling and stress responses
GS Hotamisligil, RJ Davis - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Stress-signaling pathways are evolutionarily conserved and play an important role in the
maintenance of homeostasis. These pathways are also critical for adaptation to new cellular …
maintenance of homeostasis. These pathways are also critical for adaptation to new cellular …
The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease
Alzheimer's disease (AD) is the most common form of dementia in the elderly followed by
vascular dementia. In addition to clinically diagnosed dementia, cognitive dysfunction has …
vascular dementia. In addition to clinically diagnosed dementia, cognitive dysfunction has …
The autophagosome: origins unknown, biogenesis complex
Healthy cells use autophagy as a general'housekeeping'mechanism and to survive stress,
including stress induced by nutrient deprivation. Autophagy is initiated at the isolation …
including stress induced by nutrient deprivation. Autophagy is initiated at the isolation …
[HTML][HTML] CB1 receptor signaling in the brain: extracting specificity from ubiquity
Endocannabinoids (eCBs) are amongst the most ubiquitous signaling molecules in the
nervous system. Over the past few decades, observations based on a large volume of work …
nervous system. Over the past few decades, observations based on a large volume of work …
The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells
CT Mierke - Reports on Progress in Physics, 2019 - iopscience.iop.org
The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
Senescence and aging: the critical roles of p53
Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …
Signaling networks that regulate cell migration
P Devreotes, AR Horwitz - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Stimuli that promote cell migration, such as chemokines, cytokines, and growth factors in
metazoans and cyclic AMP in Dictyostelium, activate signaling pathways that control …
metazoans and cyclic AMP in Dictyostelium, activate signaling pathways that control …