[HTML][HTML] Advances in TRP channel drug discovery: from target validation to clinical studies

AP Koivisto, MG Belvisi, R Gaudet… - Nature reviews Drug …, 2022 - nature.com
Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …

[HTML][HTML] General pathways of pain sensation and the major neurotransmitters involved in pain regulation

MF Yam, YC Loh, CS Tan, S Khadijah Adam… - International journal of …, 2018 - mdpi.com
Pain has been considered as a concept of sensation that we feel as a reaction to the
stimulus of our surrounding, putting us in harm's way and acting as a form of defense …

[PDF][PDF] Structural snapshots of TRPV1 reveal mechanism of polymodal functionality

K Zhang, D Julius, Y Cheng - Cell, 2021 - cell.com
Many transient receptor potential (TRP) channels respond to diverse stimuli and
conditionally conduct small and large cations. Such functional plasticity is presumably …

[PDF][PDF] Regulation of body temperature by the nervous system

CL Tan, ZA Knight - Neuron, 2018 - cell.com
The regulation of body temperature is one of the most critical functions of the nervous
system. Here we review our current understanding of thermoregulation in mammals. We …

[HTML][HTML] TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases

M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Controlled activation of TRPV1 channels on microglia to boost their autophagy for clearance of alpha‐synuclein and enhance therapy of Parkinson's disease

J Yuan, H Liu, H Zhang, T Wang, Q Zheng… - Advanced …, 2022 - Wiley Online Library
Parkinson's disease (PD) is characterized with accumulation of Lewy bodies with a major
component of fibrillar alpha‐synuclein (α‐syn). Herein, boosting PD therapeutic efficacy by …

Burn injury: challenges and advances in burn wound healing, infection, pain and scarring

Y Wang, J Beekman, J Hew, S Jackson… - Advanced drug delivery …, 2018 - Elsevier
Severe burn injuries are the most traumatic and physically debilitating injuries affecting
nearly every organ system and leading to significant morbidity and mortality. Early burn …

Neuronal regulation of immunity: why, how and where?

M Schiller, TL Ben-Shaanan, A Rolls - Nature Reviews Immunology, 2021 - nature.com
Neuroimmunology is one of the fastest-growing fields in the life sciences, and for good
reason; it fills the gap between two principal systems of the organism, the nervous system …

Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain

PCT Tang, JYF Chung, J Liao, MKK Chan… - Science …, 2022 - science.org
Tumor innervation is a common phenomenon with unknown mechanism. Here, we
discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de …

[HTML][HTML] Neurogenic inflammation: The participant in migraine and recent advancements in translational research

E Spekker, M Tanaka, Á Szabó, L Vécsei - Biomedicines, 2021 - mdpi.com
Migraine is a primary headache disorder characterized by a unilateral, throbbing, pulsing
headache, which lasts for hours to days, and the pain can interfere with daily activities. It …