[HTML][HTML] Advances in TRP channel drug discovery: from target validation to clinical studies
AP Koivisto, MG Belvisi, R Gaudet… - Nature reviews Drug …, 2022 - nature.com
Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …
[HTML][HTML] General pathways of pain sensation and the major neurotransmitters involved in pain regulation
Pain has been considered as a concept of sensation that we feel as a reaction to the
stimulus of our surrounding, putting us in harm's way and acting as a form of defense …
stimulus of our surrounding, putting us in harm's way and acting as a form of defense …
[PDF][PDF] Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
Many transient receptor potential (TRP) channels respond to diverse stimuli and
conditionally conduct small and large cations. Such functional plasticity is presumably …
conditionally conduct small and large cations. Such functional plasticity is presumably …
[PDF][PDF] Regulation of body temperature by the nervous system
The regulation of body temperature is one of the most critical functions of the nervous
system. Here we review our current understanding of thermoregulation in mammals. We …
system. Here we review our current understanding of thermoregulation in mammals. We …
[HTML][HTML] TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
Controlled activation of TRPV1 channels on microglia to boost their autophagy for clearance of alpha‐synuclein and enhance therapy of Parkinson's disease
J Yuan, H Liu, H Zhang, T Wang, Q Zheng… - Advanced …, 2022 - Wiley Online Library
Parkinson's disease (PD) is characterized with accumulation of Lewy bodies with a major
component of fibrillar alpha‐synuclein (α‐syn). Herein, boosting PD therapeutic efficacy by …
component of fibrillar alpha‐synuclein (α‐syn). Herein, boosting PD therapeutic efficacy by …
Burn injury: challenges and advances in burn wound healing, infection, pain and scarring
Y Wang, J Beekman, J Hew, S Jackson… - Advanced drug delivery …, 2018 - Elsevier
Severe burn injuries are the most traumatic and physically debilitating injuries affecting
nearly every organ system and leading to significant morbidity and mortality. Early burn …
nearly every organ system and leading to significant morbidity and mortality. Early burn …
Neuronal regulation of immunity: why, how and where?
M Schiller, TL Ben-Shaanan, A Rolls - Nature Reviews Immunology, 2021 - nature.com
Neuroimmunology is one of the fastest-growing fields in the life sciences, and for good
reason; it fills the gap between two principal systems of the organism, the nervous system …
reason; it fills the gap between two principal systems of the organism, the nervous system …
Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain
Tumor innervation is a common phenomenon with unknown mechanism. Here, we
discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de …
discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de …
[HTML][HTML] Neurogenic inflammation: The participant in migraine and recent advancements in translational research
Migraine is a primary headache disorder characterized by a unilateral, throbbing, pulsing
headache, which lasts for hours to days, and the pain can interfere with daily activities. It …
headache, which lasts for hours to days, and the pain can interfere with daily activities. It …