Cerebral small vessel disease (SVD) is characterized by changes in the pial and
parenchymal microcirculations. SVD produces reductions in cerebral blood flow and …

Cerebral microvascular rarefaction, the reduction in number of functional or structural small
blood vessels in the brain, is thought to play an important role in the early stages of …

Background Physical activity may attenuate age-related cognitive decline by improving
cerebrovascular function. The aim of this study was therefore to investigate effects of aerobic …

Abstract Rationale In Parkinson's disease (PD), spatial covariance analysis of 18 F-FDG
PET data has consistently revealed a characteristic PD-related brain pattern (PDRP). By …

Adequate cerebral blood flow (CBF) is essential to a healthy central nervous system (CNS).
Previous work suggests that CBF differs between men and women, and declines with age …

This study examined the associations of body mass index (BMI), waist-to-hip ratio (WHR),
waist circumference (WC), and physical activity (PA) with gray matter cerebral blood flow …

Accurate identification of brain function is necessary to understand neurocognitive aging,
and thereby promote health and well‐being. Many studies of neurocognitive aging have …

Arterial spin labeling (ASL) magnetic resonance imaging (MRI) has become a popular
approach for studying cerebral hemodynamics in a range of disorders and has recently …

Blood-brain-barrier (BBB) dysfunction is a hallmark of aging and aging-related disorders,
including cerebral small vessel disease and Alzheimer's disease. An emerging biomarker of …

Cerebral hypoperfusion is thought to contribute to cognitive decline in Alzheimer's disease,
but the natural trajectory of cerebral perfusion in cognitively healthy adults has not been well …