How to study the metabolism of new psychoactive substances for the purpose of toxicological screenings—A follow-up study comparing pooled human liver S9 …
L Wagmann, F Frankenfeld, YM Park… - Frontiers in …, 2020 - frontiersin.org
The new psychoactive substances (NPS) market continues to be very dynamic. A large
number of compounds belonging to diverse chemical groups continue to emerge. This …
number of compounds belonging to diverse chemical groups continue to emerge. This …
Zebrafish patient-derived xenograft model as a preclinical platform for uveal melanoma drug discovery
J Yin, G Zhao, H Kalirai, SE Coupland, AG Jochemsen… - Pharmaceuticals, 2023 - mdpi.com
Uveal melanoma (UM) is a rare malignant cancer of the eye, with up to 50% of patients
dying from metastasis, for which no effective treatment is available. Due to the rarity of the …
dying from metastasis, for which no effective treatment is available. Due to the rarity of the …
Evaluation of fentanyl toxicity and metabolism using a zebrafish model
T Cooman, SA Bergeron, R Coltogirone… - Journal of Applied …, 2022 - Wiley Online Library
The increased abuse of novel drugs has created a critical need for cheap and rapid in vivo
models to understand whole organism drug‐induced toxicity and metabolic impacts. One …
models to understand whole organism drug‐induced toxicity and metabolic impacts. One …
An ultrasensitive monoclonal antibody-based lateral flow immunoassay for the rapid detection of xylazine in milk
L Chen, X Hu, Y Sun, Y Xing, G Zhang - Food Chemistry, 2022 - Elsevier
In this study, a novel hapten was designed and successfully synthesized to prepared the
artificial immunogen against xylazine (XYL), then the monoclonal antibody 1H2-2C6 was …
artificial immunogen against xylazine (XYL), then the monoclonal antibody 1H2-2C6 was …
Metabolism of third generation synthetic cannabinoids using zebrafish larvae
A Morales‐Noé, FA Esteve‐Turrillas… - Drug Testing and …, 2022 - Wiley Online Library
Synthetic cannabinoids are the second largest group of new psychoactive substances
reported by the United Nations Office on Drugs and Crime in the last decade and case …
reported by the United Nations Office on Drugs and Crime in the last decade and case …
In vitro and in vivo metabolism of 3‐Methoxyeticyclidine in human liver microsomes, a zebrafish model, and two human urine samples based on liquid …
L Xu, X Liu, Z Song, P Xiang, T Hang… - Drug Testing and …, 2024 - Wiley Online Library
Methoxyeticyclidine (3‐MeO‐PCE), a phencyclidine‐type substance, has a higher N‐methyl‐
D‐aspartate receptor binding affinity than phencyclidine and an involvement in fatal …
D‐aspartate receptor binding affinity than phencyclidine and an involvement in fatal …
Phase II stanozolol metabolism study using the zebrafish water tank (ZWT) model
Stanozolol (STAN) is an androgen anabolic steroid often misused in sports competitions and
prohibited at all times by the World Anti-Doping Agency (WADA). It can be long term …
prohibited at all times by the World Anti-Doping Agency (WADA). It can be long term …
Metabolism of synthetic cathinones through the zebrafish water tank model: a promising tool for forensic toxicology laboratories
Purpose The aim of this study was to identify in vivo phase I metabolites of five psychoactive
substances: N-ethylpentylone, ethylone, methylone, α-PVP and 4-CDC, using the in house …
substances: N-ethylpentylone, ethylone, methylone, α-PVP and 4-CDC, using the in house …
Comprehensive zebrafish water tank experiment for metabolic studies of testolactone
VF Sardela, PDO Sardela, RR Lisboa, BF Matias… - Zebrafish, 2020 - liebertpub.com
Testolactone is a potent steroid aromatase (CYP19A1) inhibitor, and its main effect is a
reduction in estradiol and estrone and an increase in testosterone and androstenedione …
reduction in estradiol and estrone and an increase in testosterone and androstenedione …
Determination of the targeted carbendazim metabolites in zebrafish water tank by liquid chromatography coupled to high-resolution mass spectrometry
RM Costa, VR Matos e Chaib… - International Journal …, 2024 - Taylor & Francis
Carbendazim, a common pesticide, has shown signs of causing cancer, infertility and toxicity
to organisms. Due to its intense use, this fungicide has become a persistent compound in …
to organisms. Due to its intense use, this fungicide has become a persistent compound in …