A novel class of 7-thiazoxime quinolones was developed as potential antimicrobial agents
for the sake of bypassing resistance of quinolones. Biological assays revealed that some …

Pressure ulcers (PUs) frequently occur in individuals with limited mobility including patients
that are hospitalized or obese. PUs are challenging to resolve when infected by antibiotic …

A new class of alkynyl isoquinoline antibacterial compounds, synthesized via Sonogashira
coupling, with strong bactericidal activity against a plethora of Gram-positive bacteria …

Bacteria persister cells are immune to most antibiotics and hence compounds that are active
against persister bacteria are needed. We screened a chemical library of SF5-and SCF3 …

The Centers for Disease Control and Prevention (CDC) recognizes Neisseria gonorrhoeae
as an urgent-threat Gram-negative bacterial pathogen. Additionally, resistance to frontline …

Colistin, typically viewed as the antibiotic of last resort to treat infections caused by multidrug-
resistant (MDR) Gram-negative bacteria, had fallen out of favor due to toxicity issues. The …

A selected series of racemic α-methylene-γ-butyrolactones (AMGBL) synthesized via
allylboration or allylindation reactions were screened against methicillin-resistant …

Abstract The National Institute of Health (NIH) estimates that the majority of human microbial
infections are either linked to or directly caused by bacterial biofilms and these infections are …

Pressure ulcers (PUs) are a source of morbidity in individuals with restricted mobility
including individuals that are obese or diabetic. Infection of PUs with pathogens, including …

Methicillin-resistant Staphylococcus aureus (MRSA) infections are still difficult to treat,
despite the availability of many FDA-approved antibiotics. Thus, new compound scaffolds …