Life-long stable heart function requires a critical balance of intracellular Ca2+. Several ion
channels and pumps cooperate in a complex machinery that controls the influx, release, and …

Late sodium current has long been linked to dysrhythmia and contractile malfunction in the
heart. Despite the increasing body of accumulating information on the subject, our …

Oxaliplatin (OHP)-induced peripheral neurotoxicity (OIPN) is a frequent adverse event of
colorectal cancer treatment. OIPN encompasses a chronic and an acute syndrome. The …

Aims Eugenol is a natural compound found in the essential oils of many aromatic plants. The
compound is used as a local anesthetic because of its inhibitory effect on the voltage-gated …

Mirogabalin (MGB, Tarlige®), an inhibitor of the α2δ-1 subunit of voltage-gated Ca2+ (CaV)
channels, is used as a way to alleviate peripheral neuropathic pain and diabetic neuropathy …

Blockade of the late Na+ current (I NaL) protects from ischemia/reperfusion damage;
nevertheless, information on changes in I NaL during acute ischemia and their effect on …

Unregulated Ca2+ entry is thought to underlie muscular dystrophy. Here, we generated
skeletal-muscle-specific transgenic (TG) mice expressing the Na+-Ca2+ exchanger 1 …

Increasing evidence shows that Curcumin (Cur) has a protective effect against
cardiovascular diseases. However, the role of Cur in the electrophysiology of …

Passive ventricular remodeling is defined by the process of molecular ventricular adaptation
to different forms of cardiac pathophysiology. It includes changes in tissue architecture, such …

Background—After defibrillation of initial ventricular fibrillation (VF), it is crucial to prevent
refibrillation to ensure successful resuscitation outcomes. Inability of the late Na+ current to …