[HTML][HTML] Hypothesis: artifacts, including spurious chimeric RNAs with a short homologous sequence, caused by consecutive reverse transcriptions and endogenous …

Z Peng, C Yuan, L Zellmer, S Liu, N Xu… - Journal of Cancer, 2015 - ncbi.nlm.nih.gov
Recent RNA-sequencing technology and associated bioinformatics have led to identification
of tens of thousands of putative human chimeric RNAs, ie RNAs containing sequences from …

Heat shock protein 90 localizes to the surface and augments virulence factors of Cryptococcus neoformans

S Chatterjee, U Tatu - PLoS neglected tropical diseases, 2017 - journals.plos.org
Background Thermotolerance is an essential attribute for pathogenesis of Cryptococcus as
exemplified by the fact that only two species in the genus, which can grow at 37° C, are …

[HTML][HTML] Multimodal regulation of encystation in Giardia duodenalis revealed by deep proteomics

B Balan, SJ Emery-Corbin, JJ Sandow… - International Journal for …, 2021 - Elsevier
Cyst formation in the parasitic protist Giardia duodenalis is critical to its transmission.
Existing proteomic data quantifies only 17% of coding genes transcribed during encystation …

Heat Shock Protein 90 regulates encystation in Entamoeba

M Singh, S Sharma, A Bhattacharya… - Frontiers in microbiology, 2015 - frontiersin.org
Enteric protozoan Entamoeba histolytica is a major cause of debilitating diarrheal infection
worldwide with high morbidity and mortality. Even though the clinical burden of this parasite …

In vivo Validation of Hsp90 Trans-splicing in Giardia lamblia: Highlighting the Role of Cis-elements

S Tushir, P Jhanwar, M Benda, V Horáčková… - Journal of Molecular …, 2024 - Elsevier
Giardia lamblia causes giardiasis, one of the most common human infectious diseases
globally. Previous studies from our lab have shown that hsp90 gene of Giardia is split into …

A secreted Heat shock protein 90 of Trichomonas vaginalis

M Singh, D Beri, RK Nageshan… - PLoS Neglected …, 2018 - journals.plos.org
Trichomonas vaginalis is a causative agent of Trichomoniasis, a leading non-viral sexually
transmitted disease worldwide. In the current study, we show Heat shock protein 90 is …

Giardia lamblia Hsp90 pre‐mRNAs undergo self‐splicing to generate mature RNA in an in vitro trans‐splicing reaction

V Iyer, ST Chettiar, M Grover, P Rajyaguru… - FEBS …, 2019 - Wiley Online Library
We have previously shown that the Heat Shock Protein 90 (Hsp90) gene in G. lamblia is
expressed from two ORF s localized 777 kb apart. The pre‐mRNA s transcribed from these …

Differential antibody responses to Giardia lamblia strain variants expressing dissimilar levels of an immunogenic protein

T Garzon, L Valencia, V Dominguez… - Parasite …, 2020 - Wiley Online Library
Aims Giardia lamblia is a protozoan parasite that causes giardiasis, one of the most common
worldwide gastrointestinal diseases. For rational development of a Giardia vaccine …

Protists: Eukaryotic single-celled organisms and the functioning of their organelles.

N Yarlett, EL Jarroll, M Morada… - Advances in Microbial …, 2024 - europepmc.org
Organelles are membrane bound structures that compartmentalize biochemical and
molecular functions. With improved molecular, biochemical and microscopy tools the …

Network of Entamoeba histolytica HSP18.5 dimers formed by two overlapping [IV]‐X‐[IV] motifs

D Kurre, K Suguna - Proteins: Structure, Function, and …, 2021 - Wiley Online Library
Small heat shock proteins (sHSPs) are ATP‐independent molecular chaperones with low
molecular weight that prevent the aggregation of proteins during stress conditions and …