Organisms are constantly exposed to microbial pathogens in their environments. When a
pathogen meets its host, a series of intricate intracellular interactions shape the outcome of …

Herpesviruses have evolved exquisite virus-host interactions that co-opt or evade a number
of host pathways to enable the viruses to persist. Persistence of human cytomegalovirus …

The outcome of infection is dependent on the ability of viruses to manipulate the infected cell
to evade immunity, and the ability of the immune response to overcome this evasion …

The endoplasmic reticulum (ER) serves as a warehouse for factors that augment and control
the biogenesis of nascent proteins entering the secretory pathway. In turn, this compartment …

The coordinated activities of innate and adaptive immunity are critical for effective protection
against viruses. To counter this, some viruses have evolved sophisticated strategies to …

Human cytomegalovirus (HCMV) extensively modulates host cells, downregulating> 900
human proteins during viral replication and degrading≥ 133 proteins shortly after infection …

Butyrophilin molecules (commonly contracted to BTN), collectively take their name from the
eponymous protein in cow's milk. They are considered to be members of the B7 family of …

Human cytomegalovirus (HCMV) is an important pathogen with multiple immune evasion
strategies, including virally facilitated degradation of host antiviral restriction factors. Here …

Highlights•Many viruses have evolved to utilize the host UPS for their own benefit.•Viruses
subvert the UPS to maintain optimal level/function of viral proteins.•Viruses exploit the UPS …

Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol
biosynthetic pathway and the therapeutic target of statins, is post-transcriptionally regulated …