Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer characterized
by metastasis, drug resistance and high rates of recurrence. With a lack or targeted …

Approximately 60% of human cancers exhibit enhanced activity of ERK1 and ERK2,
reflecting their multiple roles in tumor initiation and progression. Acquired drug resistance …

Electrochemical dopamine (DA) detection has been extensively studied for the practical
diagnosis of neurological disorders. A major challenge in this system is to synthesize …

Functional template directed synthesis of hybrid siliceous fluorescent vesicle (HSFV) is
fabricated by using fluorescent vesicle as a built-in template. The template vesicle is the …

Recently, the targeting of ERK with ATP-competitive inhibitors has emerged as a potential
clinical strategy to overcome acquired resistance to BRAF and MEK inhibitor combination …

The F-recruitment site (FRS) of active ERK2 binds F-site (Phe-x-Phe-Pro) sequences found
downstream of the Ser/Thr phospho-acceptor on cellular substrates. Here we apply NMR …

The understanding of complex biological systems requires an ability to evaluate interacting
networks of genes, proteins, and cellular reactions. Enabling technologies that support the …

Protein kinases are key regulators of cell signaling and have been important therapeutic
targets for three decades. ATP-competitive drugs directly inhibit the activity of kinases but …

Inhibitors of Rho-associated protein kinase (ROCK) enzymatic activity have been shown to
reduce the invasive phenotype observed in metastatic hepatocellular carcinoma (HCC). We …

Focal adhesion kinase (FAK) has been identified as a potential therapeutic target for the
treatment of metastatic cancers. Herein we describe the design, synthesis and optimization …