Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition
Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement
on SRC function. However, a significant body of work has defined Src family kinases as key …
on SRC function. However, a significant body of work has defined Src family kinases as key …
Adherens junctions: from molecules to morphogenesis
TJC Harris, U Tepass - Nature reviews Molecular cell biology, 2010 - nature.com
How adhesive interactions between cells generate and maintain animal tissue structure
remains one of the most challenging and long-standing questions in cell and developmental …
remains one of the most challenging and long-standing questions in cell and developmental …
A nucleator arms race: cellular control of actin assembly
KG Campellone, MD Welch - Nature reviews Molecular cell biology, 2010 - nature.com
For over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of nucleation-
promoting factors and formins were the only molecules known to directly nucleate actin …
promoting factors and formins were the only molecules known to directly nucleate actin …
Myoblast fusion: lessons from flies and mice
SM Abmayr, GK Pavlath - Development, 2012 - journals.biologists.com
The fusion of myoblasts into multinucleate syncytia plays a fundamental role in muscle
function, as it supports the formation of extended sarcomeric arrays, or myofibrils, within a …
function, as it supports the formation of extended sarcomeric arrays, or myofibrils, within a …
The cell-cell adhesion molecule E-cadherin
F Van Roy, G Berx - Cellular and molecular life sciences, 2008 - Springer
This review is dedicated to E-cadherin, a calcium-dependent cell-cell adhesion molecule
with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As …
with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As …
Adherens junction: the ensemble of specialized cadherin clusters
SM Troyanovsky - Trends in cell biology, 2023 - cell.com
The cell–cell connections in adherens junctions (AJs) are mediated by transmembrane
receptors, type I cadherins (referred to here as cadherins). These cadherin-based …
receptors, type I cadherins (referred to here as cadherins). These cadherin-based …
Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation
CM Niessen, D Leckband, AS Yap - Physiological reviews, 2011 - journals.physiology.org
This review addresses the cellular and molecular mechanisms of cadherin-based tissue
morphogenesis. Tissue physiology is profoundly influenced by the distinctive organizations …
morphogenesis. Tissue physiology is profoundly influenced by the distinctive organizations …
The Arp2/3 regulatory system and its deregulation in cancer
N Molinie, A Gautreau - Physiological reviews, 2018 - journals.physiology.org
The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …
branched actin networks. When activated, the Arp2/3 complex contributes the actin …
Actin-delimited adhesion-independent clustering of E-cadherin forms the nanoscale building blocks of adherens junctions
Y Wu, P Kanchanawong, R Zaidel-Bar - Developmental cell, 2015 - cell.com
E-cadherin is the major adhesion receptor in epithelial adherens junctions, which connect
cells to form tissues and are essential for morphogenesis and homeostasis. The mechanism …
cells to form tissues and are essential for morphogenesis and homeostasis. The mechanism …
Actin-based adhesion modules mediate cell interactions with the extracellular matrix and neighboring cells
AI Bachir, AR Horwitz, WJ Nelson… - Cold Spring Harbor …, 2017 - cshperspectives.cshlp.org
Cell adhesions link cells to the extracellular matrix (ECM) and to each other and depend on
interactions with the actin cytoskeleton. Both cell–ECM and cell–cell adhesion sites contain …
interactions with the actin cytoskeleton. Both cell–ECM and cell–cell adhesion sites contain …