Hearing loss stands as the most prevalent sensory deficit among humans, posing a
significant global health challenge. Projections indicate that by 2050, approximately 10% of …

Gene therapy in pediatrics represents a cutting-edge therapeutic strategy for treating a
range of genetic disorders that manifest in childhood. Gene therapy involves the …

In the mammalian cochlea, sensory hair cells are crucial for the transduction of acoustic
stimuli into electrical signals, which are then relayed to the central auditory pathway via …

Hearing loss constitutes a major global health concern impacting approximately 1.5 billion
people worldwide. Its incidence is undergoing a substantial surge with some projecting that …

With the development of the social economy, we are exposed to increasing noise in our
daily lives. Our previous work found an ABCC1 (NM_004996. 3: c. A1769G, NP_004987. 2 …

Congenital hearing loss is the most common birth defect, estimated to affect 2–3 in every
1000 births, with~ 50–60% of those related to genetic causes. Technological advances …

Introduction: More than 5% of the world's population experience hearing impairment. The
most common form is presbycusis (age-related hearing loss; ARHL). It affects almost one in …

Abstract Phosphatidylinositol 4 kinase-β (PI4KB) plays critical roles in human genetic
diseases. In zebrafish, Pi4kb is strongly expressed in hair cells (HCs), which are necessary …

170 AUDITORY PROCESSING DISORDERS of subjects typically presents with significantly
impaired sound detection thresholds—in addition to their processing difficulties. As such …

Usher syndrome is defined as the rare genetic disorder that affects both vision and auditory.
Although the prevalence is really low, only about 4 to 17 per 100,000 people, it is noted to …