Emergence, molecular mechanisms and global spread of carbapenem-resistant Acinetobacter baumannii

M Hamidian, SJ Nigro - Microbial genomics, 2019 - microbiologyresearch.org
Acinetobacter baumannii is a nosocomial pathogen that has emerged as a global threat
because of high levels of resistance to many antibiotics, particularly those considered to be …

[HTML][HTML] Acinetobacter spp. as nosocomial pathogens: Epidemiology and resistance features

SB Almasaudi - Saudi journal of biological sciences, 2018 - Elsevier
The genus Acinetobacter is a major cause of nosocomial infections; it is increasingly being
associated with various epidemics and has become a widespread concern in a variety of …

Diversity, epidemiology, and genetics of class D β-lactamases

L Poirel, T Naas, P Nordmann - Antimicrobial agents and …, 2010 - Am Soc Microbiol
Class D β-lactamase-mediated resistance to β-lactams has been increasingly reported
during the last decade. Those enzymes also known as oxacillinases or OXAs are widely …

[HTML][HTML] Worldwide dissemination of the blaOXA-23 Carbapenemase gene of Acinetobacter baumannii1

PD Mugnier, L Poirel, T Naas… - Emerging infectious …, 2010 - ncbi.nlm.nih.gov
To assess dissemination of OXA-23–producing strains of Acinetobacter baumannii, we
obtained 20 carbapenem-resistant, OXA-23–producing isolates from different regions. Their …

β-Lactamase production in key gram-negative pathogen isolates from the Arabian Peninsula

HM Zowawi, HH Balkhy, TR Walsh… - Clinical microbiology …, 2013 - Am Soc Microbiol
Infections due to Gram-negative bacilli (GNB) are a leading cause of morbidity and mortality
worldwide. The extent of antibiotic resistance in GNB in countries of the Gulf Cooperation …

Carbapenem resistance in Acinetobacter baumannii: the molecular epidemic features of an emerging problem in health care facilities

R Zarrilli, M Giannouli, F Tomasone, M Triassi… - The Journal of Infection …, 2009 - jidc.org
Acinetobacter baumannii is an opportunistic gram-negative pathogen with increasing
relevance in a variety of nosocomial infections especially among intensive-care-unit (ICU) …

Structure and context of Acinetobacter transposons carrying the oxa23 carbapenemase gene

SJ Nigro, RM Hall - Journal of Antimicrobial Chemotherapy, 2016 - academic.oup.com
The oxa23 gene encoding the OXA-23 carbapenemase (and several minor variants of it) is
widespread in Acinetobacter baumannii clinical isolates and compromises treatment with …

How to detect carbapenemase producers? A literature review of phenotypic and molecular methods

D Hammoudi, CA Moubareck, DK Sarkis - Journal of microbiological …, 2014 - Elsevier
This review describes the current state-of-art of carbapenemase detection methods.
Identification of carbapenemases is first based on conventional phenotypic tests including …

Acquired class D β-lactamases

NT Antunes, JF Fisher - Antibiotics, 2014 - mdpi.com
The Class D β-lactamases have emerged as a prominent resistance mechanism against β-
lactam antibiotics that previously had efficacy against infections caused by pathogenic …

[HTML][HTML] Dissemination of carbapenemases producing Gram negative bacteria in the Middle East

HE Leylabadlo, M Asgharzadeh… - Iranian journal of …, 2015 - ncbi.nlm.nih.gov
The emergence and spread of carbapenemase-producing bacteria, that hydolyze most β-
lactams, including carbapenems, are a major concern of public health system worldwide …