Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseases
O Coskuner, VN Uversky - Progress in molecular biology and translational …, 2019 - Elsevier
Amyloid-β (Aβ) and α-synuclein (αS) are two intrinsically disordered proteins (IDPs) at the
centers of the pathogenesis of Alzheimer's and Parkinson's diseases, respectively. Different …
centers of the pathogenesis of Alzheimer's and Parkinson's diseases, respectively. Different …
Zinc binding promotes greater hydrophobicity in Alzheimer's Aβ42 peptide than copper binding: Molecular dynamics and solvation thermodynamics studies
S Boopathi, P Dinh Quoc Huy… - Proteins: Structure …, 2020 - Wiley Online Library
The aggregation of Aβ42 peptides is considered as one of the main causes for the
development of Alzheimer's disease. In this context, Zn2+ and Cu2+ play a significant role in …
development of Alzheimer's disease. In this context, Zn2+ and Cu2+ play a significant role in …
Structural dynamics of inosine triphosphate pyrophosphatase (ITPA) protein and two clinically relevant mutants: molecular dynamics simulations
Y Houndonougbo, B Pugh, K VanWormer… - Journal of …, 2021 - Taylor & Francis
The inosine triphosphate pyrophosphatase (ITPA) protein is responsible for removing
noncanonical purine nucleoside triphosphates from intracellular nucleotide pools. Absence …
noncanonical purine nucleoside triphosphates from intracellular nucleotide pools. Absence …
Identification of novel polymorphism and in silico analysis of caprine DNAJB3 gene
DNAJB3 acts as a cochaperon and stimulates ATPase activity of HSP family genes through
its J domain. An in vivo and in silico study was conducted to get comprehensive idea on the …
its J domain. An in vivo and in silico study was conducted to get comprehensive idea on the …
Studies on the structure and conformational flexibility of secondary structures in amyloid beta—A quantum chemical study
M Ganesan, S Paranthaman - Journal of Theoretical and …, 2020 - World Scientific
Density functional theory (DFT) calculations are performed to study the conformational
flexibility of secondary structures in amyloid beta (A β) polypeptide. In DFT, M06-2X/6-31+ G …
flexibility of secondary structures in amyloid beta (A β) polypeptide. In DFT, M06-2X/6-31+ G …