Coronavirus (CoV) genomes consist of positive-sense single-stranded RNA and are among
the largest viral RNAs known to date (∼ 30 kb). As a result, CoVs deploy sophisticated …

The Picornaviridae represent a large family of small plus-strand RNA viruses that cause a
bewildering array of important human and animal diseases. Morphogenesis is the least …

Regulation of viral RNA biogenesis is fundamental to productive SARS-CoV-2 infection. To
characterize host RNA-binding proteins (RBPs) involved in this process, we biochemically …

Myocarditis is a cardiac disease associated with inflammation and injury of the myocardium.
Several viruses have been associated with myocarditis in humans. However, coxsackievirus …

All positive-strand RNA viruses of eukaryotes studied assemble RNA replication complexes
on the surfaces of cytoplasmic membranes. Infection of mammalian cells with poliovirus and …

Hepatitis B virus (HBV), the causative agent of B-type hepatitis in humans, is the type
member of the Hepadnaviridae, hepatotropic DNA viruses that replicate via reverse …

The mechanisms and factors involved in the replication of positive stranded RNA viruses are
still unclear. Using poliovirus as a model, we show that a long-range interaction between …

In (+) RNA coronaviruses, replication and transcription of the giant∼ 30 kb genome to
produce genome‐and subgenome‐size RNAs of both polarities are mediated by a cognate …

The hepatitis C virus (HCV) is a positive-strand RNA virus belonging to the Flaviviridae. Its
genome carries at either end highly conserved nontranslated regions (NTRs) containing cis …

Double-stranded RNA virions are transcriptionally competent icosahedral particles that must
translocate across a lipid bilayer to function within the cytoplasm of the target cell …