Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …

Kv7 potassium channels regulate excitability in neuronal, sensory, and muscular cells. Here,
we describe their molecular architecture, physiological roles, and involvement in genetically …

The brain circuit projecting from the ventral tegmental area (VTA) to the nucleus accumbens
lateral shell (NAcLat) has a key role in methamphetamine (MA) addiction. As different …

The Kv7 potassium channel family encompasses five members (from Kv7. 1 to Kv7. 5)
having distinct expression pattern and functional role. Although Kv7. 1 is prevalently …

Parkinson's disease (PD) is a neurological disorder that affects the movement of the human
body. It is primarily characterized by reduced dopamine levels in the brain. The causative …

The gut-derived orexigenic peptide hormone ghrelin enhances neuronal firing in the
substantia nigra pars compacta, where dopaminergic neurons modulate the function of the …

Background: Chronic kidney disease (CKD) is one of the most common diseases in adult
age, and it is typical of older adults. Recent data suggest that almost half of the elders have …

Parkinson's disease (PD) is a debilitating neurodegenerative disease that causes a great
clinical burden. However, its exact molecular pathologies are not fully understood. Whilst …

The pathogenesis of the second major neurodegenerative disorder, Parkinson's disease
(PD), is closely associated with the dysfunction of potassium (K+) channels. Therefore, PD is …

Striatal dopamine neurotransmission is critical for normal voluntary movement, affect and
cognition. Dysfunctions of its regulation are implicated in a broad range of behaviors and …