Estrogens play a fundamental role in the physiology of the reproductive, cardiovascular,
skeletal, and central nervous systems. In this report, we review the literature in both rodents …

Many endocrine disrupting chemicals (EDCs) adversely impact estrogen signaling by
interacting with two estrogen receptors (ERs): ERα and ERβ. Though the receptors have …

Benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS) are
common clinical problems in urology. While the precise molecular etiology remains unclear …

The two oestrogen receptor subtypes α and β are hormone-regulated modulators of
intracellular signalling and gene expression. Regulation of oestrogen receptor activity is …

Estrogens regulate various normal and pathophysiological processes including cancers.
Cellular signaling by estrogens is mediated by estrogen receptor α (ERα) and β (ERβ) …

The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) necessitates strategies to identify …

Estrogens regulate key features of metabolism, including food intake, body weight, energy
expenditure, insulin sensitivity, leptin sensitivity, and body fat distribution. There are two …

Clinical data suggest that gender dimorphic profiles are emerging in terms of both drug
efficacy and adverse drug reactions (ADRs). With an increasing emphasis on individualised …

Aims Sex differences in cardiac fibrosis point to the regulatory role of 17β-Estradiol (E2) in
cardiac fibroblasts (CF). We, therefore, asked whether male and female CF in rodent and …

Estrogen receptor alpha (ERα) is involved in numerous physiological and pathological
processes, including breast cancer. Breast cancer therapy is therefore currently directed at …