Duchenne muscular dystrophy (DMD) is a fatal muscle disease caused by the lack of
dystrophin, which maintains muscle membrane integrity. We used an adenine base editor …

Following injury, cells in regenerative tissues have the ability to regrow. The mechanisms
whereby regenerating cells adapt to injury-induced stress conditions and activate the …

Duchenne muscular dystrophy (DMD), caused by mutations in the X-linked dystrophin gene,
is a lethal neuromuscular disease. Correction of DMD mutations in animal models has been …

Rationale: Absence of dystrophin in Duchenne muscular dystrophy (DMD) results in the
degeneration of skeletal and cardiac muscles. Owing to advances in respiratory …

L‐cysteine is an important sulfur‐containing amino acid being difficult to produce by
microbial fermentation. Due to the lack of high‐throughput screening methods, existing …

RNA translation to protein is paramount to creating life, yet RNA and protein correlations
vary widely across tissues, cells, and species. To investigate these perplexing results, we …

Single-cell RNA-sequencing (scRNA-seq) and related technologies to identify cell types and
measure gene expression in space, in time, and within lineages have multiplied rapidly in …

The transcriptional state of a cell provides a multi-parameter representation of gene
expression programs that reflect its identity and phenotype. However, current transcriptomic …

Heart failure remains the world's leading cause of death worldwide, with limited treatment
options aside from palliation and a desperate need for effective preclinical models. The …

Biology is driven by complex cellular processes that require precise regulation in time and in
space. However, the genetic and molecular factors underlying these behaviors are difficult to …