Plant polyamines in abiotic stress responses
Significance of naturally occurring intracellular polyamines (PAs), such as spermine,
spermidine, and putrescine, in relation to the mechanism and adaptation to combat abiotic …
spermidine, and putrescine, in relation to the mechanism and adaptation to combat abiotic …
Metabolomics and malaria biology
V Lakshmanan, KY Rhee, JP Daily - Molecular and biochemical …, 2011 - Elsevier
Metabolomics has ushered in a novel and multi-disciplinary realm in biological research. It
has provided researchers with a platform to combine powerful biochemical, statistical …
has provided researchers with a platform to combine powerful biochemical, statistical …
Multi-omics approaches to improve malaria therapy
Malaria contributes to the most widespread infectious diseases worldwide. Even though
current drugs are commercially available, the ever-increasing drug resistance problem by …
current drugs are commercially available, the ever-increasing drug resistance problem by …
Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities
LM Birkholtz, M Williams, J Niemand… - Biochemical …, 2011 - portlandpress.com
New drugs are urgently needed for the treatment of tropical and subtropical parasitic
diseases, such as African sleeping sickness, Chagas' disease, leishmaniasis and malaria …
diseases, such as African sleeping sickness, Chagas' disease, leishmaniasis and malaria …
In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies …
JVW Becker, MM Van der Merwe, AC van Brummelen… - Malaria journal, 2011 - Springer
Background Anti-malarial drug resistance threatens to undermine efforts to eliminate this
deadly disease. The resulting omnipresent requirement for drugs with novel modes of action …
deadly disease. The resulting omnipresent requirement for drugs with novel modes of action …
Clinical Proteomics of the Neglected Human Malarial Parasite Plasmodium vivax
Recent reports highlight the severity and the morbidity of disease caused by the long
neglected malaria parasite Plasmodium vivax. Due to inherent difficulties in the laboratory …
neglected malaria parasite Plasmodium vivax. Due to inherent difficulties in the laboratory …
PLP-dependent enzymes as potential drug targets for protozoan diseases
B Kappes, I Tews, A Binter, P Macheroux - Biochimica et Biophysica Acta …, 2011 - Elsevier
The chemical properties of the B6 vitamers are uniquely suited for wide use as cofactors in
essential reactions, such as decarboxylations and transaminations. This review addresses …
essential reactions, such as decarboxylations and transaminations. This review addresses …
[HTML][HTML] Mitochondrial Spermidine Synthase is essential for Blood-stage growth of the Malaria Parasite
Positively-charged polyamines are essential molecules for the replication of eukaryotic cells
and are particularly important for the rapid proliferation of parasitic protozoa and cancer …
and are particularly important for the rapid proliferation of parasitic protozoa and cancer …
Parasite polyamines as pharmaceutical targets
S Roberts, B Ullman - Current Pharmaceutical Design, 2017 - ingentaconnect.com
There is an urgent need for the identification and validation of new therapeutic targets in
protozoan parasites because currently available drugs are limited in number and …
protozoan parasites because currently available drugs are limited in number and …
[HTML][HTML] Antioxidant and hepatoprotective activities of Dicoma anomala Sond. aqueous root extract against carbon tetrachloride-induced liver damage in Wistar rats
FO Balogun, AOT Ashafa - Journal of Traditional Chinese Medicine, 2016 - Elsevier
Objective To evaluates the antioxidant and hepatoprotective potentials of Dicoma anomala
Sond.(Asteraceae) on body weight, feed and water intake, biochemical parameters and …
Sond.(Asteraceae) on body weight, feed and water intake, biochemical parameters and …