Plant polyamines in abiotic stress responses

K Gupta, A Dey, B Gupta - Acta physiologiae plantarum, 2013 - Springer
Significance of naturally occurring intracellular polyamines (PAs), such as spermine,
spermidine, and putrescine, in relation to the mechanism and adaptation to combat abiotic …

Metabolomics and malaria biology

V Lakshmanan, KY Rhee, JP Daily - Molecular and biochemical …, 2011 - Elsevier
Metabolomics has ushered in a novel and multi-disciplinary realm in biological research. It
has provided researchers with a platform to combine powerful biochemical, statistical …

Multi-omics approaches to improve malaria therapy

M Zhou, A Varol, T Efferth - Pharmacological Research, 2021 - Elsevier
Malaria contributes to the most widespread infectious diseases worldwide. Even though
current drugs are commercially available, the ever-increasing drug resistance problem by …

Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities

LM Birkholtz, M Williams, J Niemand… - Biochemical …, 2011 - portlandpress.com
New drugs are urgently needed for the treatment of tropical and subtropical parasitic
diseases, such as African sleeping sickness, Chagas' disease, leishmaniasis and malaria …

In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies …

JVW Becker, MM Van der Merwe, AC van Brummelen… - Malaria journal, 2011 - Springer
Background Anti-malarial drug resistance threatens to undermine efforts to eliminate this
deadly disease. The resulting omnipresent requirement for drugs with novel modes of action …

Clinical Proteomics of the Neglected Human Malarial Parasite Plasmodium vivax

P Acharya, R Pallavi, S Chandran, V Dandavate… - PloS one, 2011 - journals.plos.org
Recent reports highlight the severity and the morbidity of disease caused by the long
neglected malaria parasite Plasmodium vivax. Due to inherent difficulties in the laboratory …

PLP-dependent enzymes as potential drug targets for protozoan diseases

B Kappes, I Tews, A Binter, P Macheroux - Biochimica et Biophysica Acta …, 2011 - Elsevier
The chemical properties of the B6 vitamers are uniquely suited for wide use as cofactors in
essential reactions, such as decarboxylations and transaminations. This review addresses …

[HTML][HTML] Mitochondrial Spermidine Synthase is essential for Blood-stage growth of the Malaria Parasite

M Kamil, UY Kina, G Deveci, SN Akyuz, I Yilmaz… - Microbiological …, 2022 - Elsevier
Positively-charged polyamines are essential molecules for the replication of eukaryotic cells
and are particularly important for the rapid proliferation of parasitic protozoa and cancer …

Parasite polyamines as pharmaceutical targets

S Roberts, B Ullman - Current Pharmaceutical Design, 2017 - ingentaconnect.com
There is an urgent need for the identification and validation of new therapeutic targets in
protozoan parasites because currently available drugs are limited in number and …

[HTML][HTML] Antioxidant and hepatoprotective activities of Dicoma anomala Sond. aqueous root extract against carbon tetrachloride-induced liver damage in Wistar rats

FO Balogun, AOT Ashafa - Journal of Traditional Chinese Medicine, 2016 - Elsevier
Objective To evaluates the antioxidant and hepatoprotective potentials of Dicoma anomala
Sond.(Asteraceae) on body weight, feed and water intake, biochemical parameters and …